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Titolo:
Overexpression of endothelin-1 in bile duct ligated rats: correlation withactivation of hepatic stellate cells and portal pressure
Autore:
Tiehe, S; De Gottardi, A; Kappeler, A; Shaw, S; Sagesser, H; Zimmermann, A; Reichen, J;
Indirizzi:
Univ Bern, Dept Clin Pharmacol, CH-3010 Bern, Switzerland Univ Bern BernSwitzerland CH-3010 Pharmacol, CH-3010 Bern, Switzerland Univ Bern, Dept Pathol, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 ept Pathol, CH-3010 Bern, Switzerland Univ Bern, Dept Clin Res, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 t Clin Res, CH-3010 Bern, Switzerland
Titolo Testata:
JOURNAL OF HEPATOLOGY
fascicolo: 1, volume: 34, anno: 2001,
pagine: 38 - 45
SICI:
0168-8278(200101)34:1<38:OOEIBD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LIVER-INJURY; RECEPTOR ANTAGONIST; BILIARY-CIRRHOSIS; HYPERTENSIVE RATS; METALLOPROTEASE; MYOFIBROBLASTS; CONTRACTILITY; FIBROGENESIS; HEMODYNAMICS; EXCHANGE;
Keywords:
cirrhosis; portal hypertension; morphometry; hepatic stellate cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: De Gottardi, A Univ Bern, Dept Clin Pharmacol, Murtenstr 21, CH-3010 Bern,Switzerland Univ Bern Murtenstr 21 Bern Switzerland CH-3010 witzerland
Citazione:
S. Tiehe et al., "Overexpression of endothelin-1 in bile duct ligated rats: correlation withactivation of hepatic stellate cells and portal pressure", J HEPATOL, 34(1), 2001, pp. 38-45

Abstract

Background/Aims: Hepatic stellate cells (HSC) are involved in the pathogenesis of liver fibrosis; although ET-1 is increased in cirrhosis, its pathophysiological role in fibrogenesis and portal hypertension remains controversial, The aim of this study was to investigate splanchnic hemodynamics and to correlate them with changes in ET-1 expression and HSC activation in bile duct ligated (BDL) rats. Methods/Results: Expression of the ET-1 gene was increased early as measured by quantitative reverse transcriptase-polymerase chain reaction (6-fold 3 days after BDL) whereas ET-1 peptide measured by RIA increased significantly only in the late phase (30-fold at 28 days). There was a linear correlation between portal pressure and the amount of ET-1 in the portal vein (r =0.66; P = 0.003), as well as between ET-1 and the volume fraction of myofibroblasts (r = 0.80, P < 10(-7)) as assessed by morphometry and immunohistochemical staining using <alpha>-smooth muscle actin. Conclusions: During chronic liver injury activation of HSCs and of preproET-1 mRNA is accentuated in the early phase after BDL. The late increase in ET-1 peptide may indicate that this peptide is only secondarily involved inHSC activation. The correlation between ET-1 in portal vein and portal pressure suggests that ET-1 may play an important role in the development of portal hypertension. (C) 2001 European Association for the Study of the Liver, Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 12:13:05