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Titolo:
The novel guanylyl cyclase MsGC-I is strongly expressed in higher-order neuropils in the brain of Manduca sexta
Autore:
Nighorn, A; Simpson, PJ; Morton, DB;
Indirizzi:
Univ Arizona, Arizona Res Labs, Div Neurobiol, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 abs, Div Neurobiol, Tucson, AZ 85721 USA Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA Oregon Hlth Sci Univ, Dept Biol Struct & Funct, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 Funct, Portland, OR 97201 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL BIOLOGY
fascicolo: 2, volume: 204, anno: 2001,
pagine: 305 - 314
SICI:
0022-0949(200101)204:2<305:TNGCMI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSHROOM BODIES; DROSOPHILA-MELANOGASTER; PROJECTION NEURONS; CENTRAL COMPLEX; PREFERENTIAL EXPRESSION; IMMUNOREACTIVE NEURONS; ANTENNAL LOBES; IDENTIFICATION; BRAIN; COCKROACH;
Keywords:
guanylyl cyclase; cyclic GMP; immunohistochemistry; olfaction; mushroom body; hawkmoth; Manduca sexta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Nighorn, A Univ Arizona, Arizona Res Labs, Div Neurobiol, Room 611,Gould Simpson Bldg, Tucson, AZ 85721 USA Univ Arizona Room 611,Gould Simpson Bldg Tucson AZ USA 85721 SA
Citazione:
A. Nighorn et al., "The novel guanylyl cyclase MsGC-I is strongly expressed in higher-order neuropils in the brain of Manduca sexta", J EXP BIOL, 204(2), 2001, pp. 305-314

Abstract

Guanylyl cyclases are usually characterized as being either soluble (sGCs)or receptor (rGCs), We have recently cloned a novel guanylyl cyclase, MsGC-I, from the developing nervous system of the hawkmoth Manduca sexta that cannot be classified as either an sGC or an rGC, MsGC-I shows highest sequence identity with receptor guanylyl cyclases throughout its catalytic and dimerization domains, but does not contain the ligand-binding, transmembrane or kinase-like domains characteristic of receptor guanylyl cyclases. In addition, MsGC-I contains a C-terminal extension of 149 amino acid residues. In this paper, we report the expression of MsGC-I in the adult. Northern blots show that it is expressed preferentially in the nervous system, with high levels in the pharate adult brain and antennae. In the antennae, immunohistochemical analyses show that it is expressed in the cell bodies and dendrites, but not axons, of olfactory receptor neurons. In the brain, it is expressed in a variety of sensory neuropils including the antennal and optic lobes. It is also expressed in structures involved in higher-order processing including the mushroom bodies and central complex. This complicated expression pattern suggests that this novel guanylyl cyclase plays an important role in mediating cyclic GMP levels in the nervous system of Manduca sexta.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:01:29