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Titolo:
Chronic autoimmune thrombopenia/neutropenia in a boy with persistent parvovirus B19 infection
Autore:
Scheurlen, W; Ramasubbu, K; Wachowski, O; Hemauer, A; Modrow, S;
Indirizzi:
Univ Heidelberg, Kinderklin Mannheim, Fak Klin Med Mannheim, D-68167 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68167 heim, D-68167 Mannheim, Germany Univ Regensburg, Inst Mikrobiol & Hyg, D-93042 Regensburg, Germany Univ Regensburg Regensburg Germany D-93042 , D-93042 Regensburg, Germany
Titolo Testata:
JOURNAL OF CLINICAL VIROLOGY
fascicolo: 3, volume: 20, anno: 2001,
pagine: 173 - 178
SICI:
1386-6532(200102)20:3<173:CATIAB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
B19-ASSOCIATED HEMOPHAGOCYTIC SYNDROME; IDIOPATHIC THROMBOCYTOPENIC PURPURA; NONSTRUCTURAL PROTEIN; NEUTROPENIA; ANTIBODIES; VIRUS; CHILDHOOD; CHILDREN; THERAPY; DISEASE;
Keywords:
chronic autoimmune neutropenia/thrombocytopenia; parvovirus B19 infection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Scheurlen, W Univ Heidelberg, Kinderklin Mannheim, Fak Klin Med Mannheim, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany Univ Heidelberg Theodor Kutzer Ufer 1-3 Mannheim Germany D-68167
Citazione:
W. Scheurlen et al., "Chronic autoimmune thrombopenia/neutropenia in a boy with persistent parvovirus B19 infection", J CLIN VIRO, 20(3), 2001, pp. 173-178

Abstract

Objective: We report an Ii-year-old boy presenting with splenomegaly, chronic thrombocytopenia and concordant neutropenia. Results: In contrast to autoantibodies against platelets, there were no detectable neutrophil-specific autoantibodies present in this patient. Extensive serologic investigations revealed increased IgM- and IgG-antibody titers against parvovirus B19. Anested polymerase chain reaction (PCR) showed parvovirus B19-specific sequences in the patient's bone-marrow cells but not in the serum. Specific antibodies against the structural proteins VP1 and VP2 in addition to those against non-structural protein NS1 of parvovirus B19 were detected by Westernblot analysis. Thrombocytopenia and neutropenia responded to immunosuppressive therapy and subsequent splenectomy, the latter being necessary due to severe side-effects of steroid medication. Conclusion: Autoimmune thrombocytopenia/neutropenia may have been triggered and/or sustained by a chronic parvovirus B19 infection. Patients with this very rare disorder should be screened for this virus. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:33:55