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Titolo:
A double-blind trial of a new inactivated, trivalent, intra-nasal anti-influenza vaccine in general practice: relationship between immunogenicity andrespiratory morbidity over the winter of 1997-98
Autore:
Kiderman, A; Furst, A; Stewart, B; Greenbaum, E; Morag, A; Zakay-Rones, Z;
Indirizzi:
Hebrew Univ Jerusalem, Hadassah Med Sch, Div Family Med, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 -91120 Jerusalem, Israel Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Virol, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 -91120 Jerusalem, Israel Hebrew Univ Jerusalem, Hadassah Med Sch, Clin Virol Unit, IL-91120 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 -91120 Jerusalem, Israel Israel Gen Insurance Plan Kupat Holim, Jerusalem, Israel Israel Gen Insurance Plan Kupat Holim Jerusalem Israel erusalem, Israel
Titolo Testata:
JOURNAL OF CLINICAL VIROLOGY
fascicolo: 3, volume: 20, anno: 2001,
pagine: 155 - 161
SICI:
1386-6532(200102)20:3<155:ADTOAN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY; ADULTS; TRACT;
Keywords:
influenza; intra-nasal anti-influenza vaccine; healthy populations; respiratory morbidity; general practice; family practice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Furst, A Hebrew Univ Jerusalem, Hadassah Med Sch, Div Family Med, IL-91120Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 rusalem, Israel
Citazione:
A. Kiderman et al., "A double-blind trial of a new inactivated, trivalent, intra-nasal anti-influenza vaccine in general practice: relationship between immunogenicity andrespiratory morbidity over the winter of 1997-98", J CLIN VIRO, 20(3), 2001, pp. 155-161

Abstract

Background: Influenza is responsible for considerable morbidity not only among older people but in younger age groups as well. However, most large-scale anti-influenza vaccination campaigns are still aimed principally at theelderly using injectable vaccines. Until now there has been much less emphasis on targeting younger populations or using intra-nasal vaccines in massanti-influenza immunisation programmes. Objectives: To assess the immunogenicity of a new inactivated intra-nasal anti-influenza vaccine and to measure its effect on respiratory morbidity in a volunteer general practice population. Study design: A prospective, double-blind, placebo-controlled trialusing the new vaccine was carried out over the winter of 1997-98 on 274 healthy patients aged 12-60 from three Israeli general practices, 182 in the vaccine group and 92 in the placebo group. Following vaccination the changes in the antigen levels and episodes of respiratory illness in the vaccine and placebo groups were measured. Results: Protective antibody levels occurred after a single dose of vaccine [influenza HIN1, 41% immune pre-vaccination to 73% post-vaccination; influenza H3N2, 35-66%; influenza B, 27-64%]. Between January and March 1998, when influenza activity was at a peak in Israel, the average number of respiratory illness events in the vaccine group[14 events/100 subjects per month] was significantly less than in the placebo group [22 events/100 subjects per month]; similarly, the average numberof respiratory illness days in the vaccine group over the same period [69 days/100 subjects per month] was significantly less than in the placebo group [117 days/100 subjects per month]. Conclusions: The new vaccine possessed significant immunogenicity and was associated with a significant reduction in respiratory morbidity among a group of healthy older children and adults. Since intra-nasal vaccine's are simpler to administer and more acceptable to the public than injections the vaccine's potential for use in routineanti-influenza vaccination campaigns seems promising, especially if its beneficial effects are also reproducible in more medically vulnerable populations. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:34:23