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Titolo:
Role of iron in experimental Mycobacterium avium infection
Autore:
Gomes, MS; Boelaert, JR; Appelberg, R;
Indirizzi:
Univ Porto, Lab Microbiol & Immunol Infect, Inst Mol & Cell Biol, P-4150180 Porto, Portugal Univ Porto Porto Portugal P-4150180 Cell Biol, P-4150180 Porto, Portugal Inst Super Ciencias Saude Norte, Paredes, Portugal Inst Super Ciencias Saude Norte Paredes Portugal rte, Paredes, Portugal Algemeen Ziekenhuis St Jan, Unit Renal & Infect Dis, Brugge, Belgium Algemeen Ziekenhuis St Jan Brugge Belgium & Infect Dis, Brugge, Belgium
Titolo Testata:
JOURNAL OF CLINICAL VIROLOGY
fascicolo: 3, volume: 20, anno: 2001,
pagine: 117 - 122
SICI:
1386-6532(200102)20:3<117:ROIIEM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; NK-CELL-ACTIVITY; MURINE MACROPHAGES; GAMMA-INTERFERON; INTRACELLULAR PATHOGENS; LEGIONELLA-PNEUMOPHILA; SCHISTOSOMA-MANSONI; INNATE RESISTANCE; HIV-INFECTION; SYNDROME AIDS;
Keywords:
iron; HIV; AIDS; opportunistic infections;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Gomes, MS Univ Porto, Lab Microbiol & Immunol Infect, Inst Mol & Cell Biol, Rua Campo Alegre 823, P-4150180 Porto, Portugal Univ Porto Rua Campo Alegre 823 Porto Portugal P-4150180 rtugal
Citazione:
M.S. Gomes et al., "Role of iron in experimental Mycobacterium avium infection", J CLIN VIRO, 20(3), 2001, pp. 117-122

Abstract

Background: Acquired immunodeficiency syndrome (AIDS) patients exhibit alterations in the metabolism of iron that lead to increased deposition of this element in the tissues. Such alterations may underlie an increased susceptibility of AIDS patients to mycobacterial infections, namely by Mycobacterium avium. Objectives: The understanding of the role of iron metabolism during M. avium infections in mouse models may allow the design of new therapies based on the manipulation of iron stores. Study design: In vitro macrophage cultures and in vivo mouse studies of iron depletion and iron overload are used to assess mycobacterial multiplication and testing of the efficacyof iron depletion strategies such as the use of iron chelators. Results and conclusions: The levels of iron loading of macrophages in vitro or in vivo affect the growth of M. avium. The currently available iron chelators have poor efficacy in depleting the macrophage iron stores and, therefore, have a poor impact on the infection. Therefore, newer drugs are required that may be used in the context of in vivo infections such as in the case of affected AIDS patients. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 05:30:51