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Titolo:
Iron status and the outcome of HIV infection: an overview
Autore:
Gordeuk, VR; Delanghe, JR; Langlois, MR; Boelaert, JR;
Indirizzi:
Howard Univ, Coll Med, Ctr Sickle Cell Dis, Washington, DC 20059 USA Howard Univ Washington DC USA 20059 le Cell Dis, Washington, DC 20059 USA Howard Univ, Coll Med, Dept Med, Washington, DC 20059 USA Howard Univ Washington DC USA 20059 d, Dept Med, Washington, DC 20059 USA State Univ Ghent, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 Univ Ghent, B-9000 Ghent, Belgium AZ St Jan Brugge, Brugge, Belgium AZ St Jan Brugge Brugge BelgiumAZ St Jan Brugge, Brugge, Belgium
Titolo Testata:
JOURNAL OF CLINICAL VIROLOGY
fascicolo: 3, volume: 20, anno: 2001,
pagine: 111 - 115
SICI:
1386-6532(200102)20:3<111:ISATOO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PNEUMOCYSTIS-CARINII PNEUMONIA; INTERFERON-GAMMA; SECONDARY PROPHYLAXIS; THALASSEMIC PATIENTS; FREE-RADICALS; NITRIC-OXIDE; SURVIVAL; DISEASE; DESFERRIOXAMINE; METABOLISM;
Keywords:
HIV; outcome of HIV infection; iron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Gordeuk, VR Howard Univ, Coll Med, Ctr Sickle Cell Dis, Washington, DC 20059 USA Howard Univ Washington DC USA 20059 Washington, DC 20059 USA
Citazione:
V.R. Gordeuk et al., "Iron status and the outcome of HIV infection: an overview", J CLIN VIRO, 20(3), 2001, pp. 111-115

Abstract

Background: Theoretical considerations and experiments in the laboratory suggest that excessive iron stores may have an adverse effect on immunity. If so, high iron stores might be especially a problem in patients with humanimmunodeficiency virus (HIV) infection. Objective and study design: Reviewpublished clinical studies that provide information regarding the effect of iron status on the outcome of HIV infection. Results: Four clinical observations have provided some perspective on the effect of iron status on the outcome of HIV-1 infection. First, in a restrospective study of HIV-positive thalassemia major patients, the rate of progression of HIV disease was significantly faster in patients with lower doses of desferrioxamine and higher serum ferritin concentrations. Second, the inadvertent simultaneous administration of low doses of oral iron with dapsone for the prophylaxis of Pneumocystis carinii pneumonia in HIV-positive patients may have been associated with excess mortality. Third, a study of haptoglobin polymorphisms in HIV-positive subjects indicated that the haptoglobin 2-2 polymorphism is associated with higher iron stores and shortened survival as compared with thehaptoglobin 1-1 or 2-1 phenotypes. Fourth, a retrospective study of bone marrow macrophage iron in HIV-positive patients suggested that survival is shorter with high iron stores. Conclusion: These four observations raise thepossibility that high iron status may adversely influence the outcome of HIV-1 infection. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:47:17