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Titolo:
Urinary levels of interleukin-8 (IL-8) and disease activity in patients with IgA nephropathy
Autore:
Huang, FX; Horikoshi, S; Kurusu, A; Shibata, T; Suzuki, S; Funabiki, K; Shirato, I; Tomino, Y;
Indirizzi:
Juntendo Univ, Sch Med, Dept Med, Div Nephrol,Bunkyo Ku, Tokyo 1138421, Japan Juntendo Univ Tokyo Japan 1138421 ephrol,Bunkyo Ku, Tokyo 1138421, Japan
Titolo Testata:
JOURNAL OF CLINICAL LABORATORY ANALYSIS
fascicolo: 1, volume: 15, anno: 2001,
pagine: 30 - 34
SICI:
0887-8013(2001)15:1<30:ULOI(A>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSION; GLOMERULI; CYTOKINES; GLOMERULONEPHRITIS; ACTIVATION;
Keywords:
IL-8; ELISA; urine; renal histology; IgA nephropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Tomino, Y Juntendo Univ, Sch Med, Dept Med, Div Nephrol,Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan Juntendo Univ 2-1-1 Hongo Tokyo Japan 1138421 yo 1138421, Japan
Citazione:
F.X. Huang et al., "Urinary levels of interleukin-8 (IL-8) and disease activity in patients with IgA nephropathy", J CL LAB AN, 15(1), 2001, pp. 30-34

Abstract

Using quantitative sandwich ELISA, we studied 27 patients with IgA nephropathy to determine whether the levels of urinary IL-8 might reflect the disease activity. The levels of urinary IL-8 in patients with advanced stage IgA nephropathy were significantly higher than those in the patients with themild stage of this disease, or in the healthy controls. The results showeda positive significant correlation between the levels of IL-8 and disease activity, i.e., between levels of urinary protein and urinary casts. A significant correlation between levels of urinary IL-8 and tubular function damage was also found. It was thus suggested that measurement of urinary IL-8 might be useful in evaluating the degree of renal injuries and/or prognosisin patients with IgA nephropathy. J. Clin. Lab. Anal. 15:30-34, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:22:11