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Titolo:
Serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy
Autore:
Tomino, Y; Suzuki, S; Gohda, T; Kobayashi, M; Horikoshi, S; Imai, H; Saito, T; Kawamura, T; Yorioka, N; Harada, T; Yasumoto, Y; Kida, H; Kobayashi, Y; Endoh, M; Sato, H; Saito, K;
Indirizzi:
Juntendo Univ, Sch Med, Dept Med, Div Nephrol,Bunkyo Ku, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 d, Div Nephrol,Bunkyo Ku, Tokyo 113, Japan Akita Univ, Sch Med, Dept Internal Med 3, Akita, Japan Akita Univ Akita Japan Univ, Sch Med, Dept Internal Med 3, Akita, Japan Tohoku Univ, Sch Med, Dept Internal Med 2, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 rnal Med 2, Sendai, Miyagi 980, Japan Jikei Univ, Sch Med, Dept Internal Med 2, Tokyo, Japan Jikei Univ Tokyo Japan Univ, Sch Med, Dept Internal Med 2, Tokyo, Japan Hiroshima Univ, Sch Med, Dept Internal Med 2, Hiroshima, Japan Hiroshima Univ Hiroshima Japan d, Dept Internal Med 2, Hiroshima, Japan Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 852, Japan Nagasaki Univ Nagasaki Japan 852 ept Internal Med 2, Nagasaki 852, Japan Kagoshima Univ, Sch Med, Fac Med, Dept Internal Med 2, Kagoshima 890, Japan Kagoshima Univ Kagoshima Japan 890 Internal Med 2, Kagoshima 890, Japan Kanazawa Natl Hosp, Dept Internal Med 1, Kanazawa, Ishikawa, Japan Kanazawa Natl Hosp Kanazawa Ishikawa Japan 1, Kanazawa, Ishikawa, Japan Kitasato Univ, Sch Med, Dept Internal Med, Sagamihara, Kanagawa 228, JapanKitasato Univ Sagamihara Kanagawa Japan 228 gamihara, Kanagawa 228, Japan Tokai Univ, Sch Med, Dept Internal Med, Div Nephrol & Metab, Isehara, Kanagawa 25911, Japan Tokai Univ Isehara Kanagawa Japan 25911 b, Isehara, Kanagawa 25911, Japan Sapporo City Gen Hosp, Dept Pathol, Cent Lab, Sapporo, Hokkaido, Japan Sapporo City Gen Hosp Sapporo Hokkaido Japan b, Sapporo, Hokkaido, Japan Dade Behring Ltd, Mkt Div, Tokyo, Japan Dade Behring Ltd Tokyo JapanDade Behring Ltd, Mkt Div, Tokyo, Japan
Titolo Testata:
JOURNAL OF CLINICAL LABORATORY ANALYSIS
fascicolo: 1, volume: 15, anno: 2001,
pagine: 25 - 29
SICI:
0887-8013(2001)15:1<25:SCCMPT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; HUMAN GAMMA-TRACE; BEHRING NEPHELOMETER; PROTEINS;
Keywords:
serum cystatin C; prognostic stage; IgA nephropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Tomino, Y Juntendo Univ, Sch Med, Dept Med, Div Nephrol,Bunkyo Ku, 2-1-1 Hongo, Tokyo 113, Japan Juntendo Univ 2-1-1 Hongo Tokyo Japan 113 ngo, Tokyo 113, Japan
Citazione:
Y. Tomino et al., "Serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy", J CL LAB AN, 15(1), 2001, pp. 25-29

Abstract

The relationship between the levels of serum cystatin C and the prognosticstages of IgA nephropathy was determined in a multicenter trial in Japan. The levels of serum cystatin C in patients with IgA nephropathy were measured using the Dade Behring N Latex Cystain C assay. In 1995, the Joint Committee of the Special Study Group on Progressive Glomerular Diseases, Ministry of Health and Welfare of Japan, and the Japanese Society of Nephropathy reported four prognostic stages. These are: good prognosis group (Group I), relatively good prognosis group (Group II), relatively poor prognosis group(Group III), and poor prognosis group (Group IV), for this disease. Three-hundred and six patients with IgA nephropathy and other glomerular diseaseswere examined. There were no significant changes in the levels of serum creatinine (Cr) or creatinine clearance (CCr) between Group I and Group II. The mean levels of serum cystatin C in Group II were significantly higher than those in Group I (P < 0.05). The mean levels of serum cystatin C in Group III or IV were significantly higher than those in Group I (P < 0.001, P <0.005, respectively). These suggest that the measurement of serum cystatinC may predict the prognostic stages of patients with IgA nephropathy priorto renal biopsy. J. Clin. Lab. Anal. 15:25-29, 2001. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 29/03/20 alle ore 09:09:05