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Titolo:
Molecular genetics in acute and chronic leukemias
Autore:
Burmeister, T; Thiel, E;
Indirizzi:
Free Univ Berlin, Med Klin 3, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 Klin 3, D-12200 Berlin, Germany
Titolo Testata:
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
fascicolo: 2, volume: 127, anno: 2001,
pagine: 80 - 90
SICI:
0171-5216(200102)127:2<80:MGIAAC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE PROMYELOCYTIC LEUKEMIA; POLYMERASE CHAIN-REACTION; MINIMAL RESIDUAL DISEASE; ACUTE MYELOID-LEUKEMIA; TRANS-RETINOIC ACID; HEMATOLOGICAL MALIGNANCIES; T(15-17) TRANSLOCATION; CHROMOSOME-ABERRATIONS; CLINICAL-SIGNIFICANCE;
Keywords:
leukemia; chromosomal translocation; fusion gene; minimal residual disease; oncoviruses;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Burmeister, T Free Univ Berlin, Med Klin 3, Hindenburgdamm 30, D-12200 Berlin, Germany Free Univ Berlin Hindenburgdamm 30 Berlin Germany D-12200 y
Citazione:
T. Burmeister e E. Thiel, "Molecular genetics in acute and chronic leukemias", J CANC RES, 127(2), 2001, pp. 80-90

Abstract

The application of molecular biological techniques in malignant hematologic diseases, particularly leukemias, has led to a rapid increase in knowledge and a deeper insight into the pathobiology of these diseases. Leukemia isa very heterogeneous disease on the molecular level. Clonal chromosomal abnormalities can be found in the vast majority of cases. A broader understanding of the underlying molecular changes has enabled the development of risk-adapted therapy regimens with improved outcome. One example is the application of molecular genetic techniques for detecting small numbers of leukemia cells after therapy ("minimal residual disease"). This allows the early preclinical recognition and prevention of relapse. This study gives a shortoverview of the current status of molecular genetics in human leukemias and its implications for the therapy and prognosis of these diseases. The following topics are covered: generation of oncogenic fusion genes or dysregulation of protooncogenes by chromosomal translocations, detection of minimalresidual disease based on clonally rearranged immunoglobulin or T-cell receptor genes or on leukemia-specific fusion genes, monitoring bone marrow chimerism after allogeneic transplantation by molecular genetic techniques, and the role of oncogenic herpesviruses and retroviruses in human hematologic malignancies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:04:49