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Titolo:
Cholesterol solubilization in aqueous micellar solutions of quillaja saponin, bile salts, or nonionic surfactants
Autore:
Mitra, S; Dungan, SR;
Indirizzi:
Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA Univ CalifDavis Davis CA USA 95616 m Engn & Mat Sci, Davis, CA 95616 USA Univ Calif Davis, Dept Food Sci & Technol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 od Sci & Technol, Davis, CA 95616 USA
Titolo Testata:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
fascicolo: 1, volume: 49, anno: 2001,
pagine: 384 - 394
SICI:
0021-8561(200101)49:1<384:CSIAMS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY-CHOLESTEROL; ADJUVANT ACTIVITY; SAPONARIA MOLINA; FATTY-ACIDS; MIXTURES; TEMPERATURE; DISSOLUTION; AGGREGATION; CAPACITIES; SEPARATION;
Keywords:
micellar solutions; Triton X-100; Tween 20; surfactant mixtures; surface tension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Dungan, SR Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USAUniv Calif Davis Davis CA USA 95616 t Sci, Davis, CA 95616 USA
Citazione:
S. Mitra e S.R. Dungan, "Cholesterol solubilization in aqueous micellar solutions of quillaja saponin, bile salts, or nonionic surfactants", J AGR FOOD, 49(1), 2001, pp. 384-394

Abstract

Quillaja saponin in aqueous solution enhanced cholesterol solubility by asmuch as a factor of 10(3) at room temperature. Increased temperature and [NaCl] increased cholesterol solubility, whereas solubility was greatest at an aqueous pH of 4.6 at 298 K. Although various saponin sources were observed to differ in their abilities to solubilize cholesterol, trends in their solubilization properties with changing aqueous phase parameters were consistent. Surfactant molecules containing fused-ring structures as their hydrophobic portion, such as sodium cholate, sodium deoxycholate, and quillaja saponin, solubilized cholesterol significantly better than the linear hydrocarbon chain surfactants Tween 20 and Triton X-100. Mixtures of surfactants studied were found to exhibit synergistic effects: they formed micelles at lower concentrations than did those formed by the individual surfactants themselves, and they had a better ability to solubilize cholesterol. The knowledge obtained from these studies improves our understanding of cholesterolassociation with saponin and other types of surfactants and enhances the potential for using saponins for the solubilization and extraction of hydrophobic solutes in various pharmacological and industrial applications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:23:07