Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Long-term normal tissue effects of intraoperative electron radiation therapy (IOERT): Late sequelae, tumor recurrence, and second malignancies
Autore:
Azinovic, I; Calvo, FA; Puebla, F; Aristu, J; Martinez-Monge, R;
Indirizzi:
Univ Navarra, Dept Oncol, Clin Univ, E-31080 Pamplona, Spain Univ NavarraPamplona Spain E-31080 , Clin Univ, E-31080 Pamplona, Spain
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 2, volume: 49, anno: 2001,
pagine: 597 - 604
SICI:
0360-3016(20010201)49:2<597:LNTEOI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTERNAL-BEAM IRRADIATION; NATIONAL-CANCER-INSTITUTE; PERIPHERAL-NERVE; CANINE MODEL; COLORECTAL-CANCER; RADIOTHERAPY IORT; TOLERANCE; NEUROPATHIES; RESECTION; CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Azinovic, I Univ Navarra, Dept Oncol, Clin Univ, E-31080 Pamplona, Spain Univ Navarra Pamplona Spain E-31080 E-31080 Pamplona, Spain
Citazione:
I. Azinovic et al., "Long-term normal tissue effects of intraoperative electron radiation therapy (IOERT): Late sequelae, tumor recurrence, and second malignancies", INT J RAD O, 49(2), 2001, pp. 597-604

Abstract

Purpose: To evaluate long-term survivors treated with intraoperative electron radiation therapy (IOERT) as a component, with particular emphasis on analyzing late normal tissue toxicity, second malignancies, and patterns of delayed tumor recurrence. Methods and Materials: From September 1984 to December 1991, 739 patients were treated with IOERT, One hundred ninety;five patients were alive at least 5 years after IOERT (26%), Patient information regarding late complications related symptoms, incidence of second tumors, and delayed relapses wereanalyzed, Normal tissue changes were categorized by a modified LENT/SOMA scale (Grade 0-1, Grade 2, and Grade 3-4), Risk of late toxicity was groupedby type and number of cancer treatment modalities employed in each patient: surgery + IOERT alone (17 patients, 9%); IOERT + external radiotherapy a chemosensibilization (90 patients, 46%); IOERT a external radiotherapy a neoadjuvant chemotherapy (+/- previous radiotherapy) (88 patients, 45%). Biologic effective doses (BED) were calculated for alpha/beta = 3.5 for late fibrosis,Results: With a mean follow-up time of the surviving patients of 94 months(range: 55-162 months), 99 patients (51%) had Grade 0-1 toxicity, 52 (27%)had Grade 2, and 44 patients (23%) presented Grade 3-4 late normal tissue complications. Risk groups by treatment intensity did correlate with severity of observed toxicity (p < 0.001), BED estimations did not correlate withlate normal tissue damage. The tumor type with higher toxicity scores was bone sarcoma (28/46, 60%), in which the estimated BED = 100.5 Gy, Peripheral neuropathy was the dominant IOERT-specific toxicity present in 24 patients (12%), Second malignancies were identified in 8 patients (4%), none inside the IOERT held (3 questionable to be marginal to the external beam radiotherapy volume). In 36 patients (18%), recurrence of the originally treated tumor was detected, including 11(7%)local relapses. Conclusions: The incidence of late normal tissue complications (50%) and severity (23%) is significant in a cohort of patients surviving more the 5 years after IOERT. The understanding of the contribution of IOERT to late tissue damage requires specific analysis. Peripheral neuropathy is a characteristic finding in IOERT trials. Second malignancies inside the IOERT field were not identified during the study period. The risk of recurrences, including local failures, requires an intensive follow-up of long-term survivorsfrom IOERT trials. (C) 2001 Elsevier Science inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 00:02:24