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Titolo:
Acute stimulation of leptin concentrations in humans during hyperglycemic hyperinsulinemia. Influence of free fatty acids and fasting
Autore:
Stefan, N; Fritsche, A; Haring, H; Stumvoll, M;
Indirizzi:
Univ Tubingen, Med Klin, Abt Endokrinol Stoffwechsel & Pathobiochem, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 iochem, D-72076 Tubingen, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 138 - 142
SICI:
0307-0565(200101)25:1<138:ASOLCI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA LEPTIN; SERUM LEPTIN; OBESE GENE; ADIPOSE-TISSUE; NORMAL-WEIGHT; IN-VITRO; INSULIN; ADIPOCYTES; CULTURE; VIVO;
Keywords:
obesity; free fatty acids; insulin; glucose; triglyceride synthesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Stumvoll, M Univ Tubingen, Med Klin, Abt Endokrinol Stoffwechsel & Pathobiochem, Otfried Muller Str 10, D-72076 Tubingen, Germany Univ Tubingen Otfried Muller Str 10 Tubingen Germany D-72076
Citazione:
N. Stefan et al., "Acute stimulation of leptin concentrations in humans during hyperglycemic hyperinsulinemia. Influence of free fatty acids and fasting", INT J OBES, 25(1), 2001, pp. 138-142

Abstract

OBJECTIVE: To assess the acute regulation of leptin concentrations by insulin, glucose and free fatty acids (FFAs). DESIGN: Four protocols: saline control experiment (CON); hyperglycemic clamps (similar to 8.3 mmol/l, 120 min) after an overnight fast (12 FAST); after a 36 h fast (36 FAST); and after a 36 h fast during which Intralipid/heparin was given over the last 24 h (36 FAST + FFA). SUBJECTS: Lean, young, healthy volunteers; control group (n = 6), experimental group (n = 6). MEASUREMENTS: Serum leptin concentrations. RESULTS: Glucose and insulin concentrations were similar during the three clamp protocols. Average FFAs during the last 60 min of the clamp were 671 /- 68 muM (CON),109 +/- 15 muM (12 FAST), 484 +/- 97 muM (36 FAST) and 1762 +/- 213 muM (36 FAST + FFA). Leptin concentrations decreased similarly during 36 FAST and 36 FAST + FFA. Leptin concentrations at 120 min (expressedas percentage of mean basal value) were 0.82 +/- 0.02 (CON), 0.93 +/- 0.08(12 FAST) (P = 0.29), 1.19 +/- 0.06 (36 FAST) (P < 0.01) and 1.44 +/- 0.12(36 FAST + FFA) (P < 0.01). CONCLUSION: During a one-day fast leptin concentrations decrease regardless of maintainance of an isocaloric balance. During acute hyperinsulinemic hyperglycemia leptin concentrations increase only after a preceding fast. This increase was most pronounced during simultaneous elevation of FFAs. Overall, our findings are compatible with the hypothesis that leptin secretion may be coupled to triglyceride synthesis rather than to the absolute lipid content of the adipocyte.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:25:33