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Titolo:
Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men
Autore:
Chu, NF; Stampfer, MJ; Spiegelman, D; Rifai, N; Hotamisligil, GS; Rimm, EB;
Indirizzi:
Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Community Med, Taipei, Taiwan Tri Serv Gen Hosp Taipei Taiwan Ctr, Dept Community Med, Taipei, Taiwan Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA Harvard UnivBoston MA USA 02115 bl Hlth, Dept Nutr, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Div Biol Sci, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hlth, Div Biol Sci, Boston, MA 02115 USA Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hlth, Dept Biostat, Boston, MA 02115 USA Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 sp, Dept Lab Med, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Harvard Univ BostonMA USA 02115 Sch Med, Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 mens Hosp, Boston, MA 02115 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 106 - 114
SICI:
0307-0565(200101)25:1<106:DALFIR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALE HEALTH-PROFESSIONALS; OBESE GENE-PRODUCT; SERUM LEPTIN; SHORT-TERM; BODY-FAT; CIGARETTE-SMOKING; ADIPOSE-TISSUE; FOOD-INTAKE; WOMEN; INSULIN;
Keywords:
leptin; dietary fat; physical activity; cigarette smoking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Chu, NF Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Community Med, POB 90048-509, Taipei, Taiwan Tri Serv Gen Hosp POB 90048-509 Taipei Taiwan 09, Taipei, Taiwan
Citazione:
N.F. Chu et al., "Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men", INT J OBES, 25(1), 2001, pp. 106-114

Abstract

OBJECTIVE: Leptin, the product of the obesity (ob) gene, is a multi-functional polypeptide that is important in energy metabolism, which is strongly correlated with body fat mass and body mass index (BMI). In a recent prospective study, we found that leptin was positively associated with 4 y weightgain among overweight and obese men. This suggests that leptin resistance,marked by hyperleptinemia among obese subjects, may be an important markerfor weight gain. The purpose of this study is to evaluate whether modifiable dietary and lifestyle factors are associated with plasma leptin concentrations among US men. METHODS: We included 268 men aged 47-83 y(who were free of cardiovascular disease, diabetes mellitus and cancer, except nonmelanoma skin cancer) fromthe ongoing Health Professionals Follow-up Study. These subjects completeda detailed dietary and lifestyle questionnaire (including cigarette smoking, alcohol drinking and physical activity) and provided a fasting venous blood sample in 1994. All blood samples were stored in a deep freeze (- 70 degreesC) for 4-5 y before being analyzed. Plasma leptin concentrations were measured by radioimmunoassay. RESULTS: Men in the highest quintile of plasma leptin (mean = 14.4 ng/ml) weighed more, were less physically active, and had higher total and saturated fat and cholesterol intake than men in the lowest quintile (mean = 3.0 ng/ml). Physical activity and current smoking were inversely associated withplasma leptin concentrations (P<0.001). A 20 MET difference in physical activity per week (equivalent to approximately 3 h of jogging) was associatedwith 0.38 - 0.58 ng/ml lower plasma leptin concentrations for normal weight and overweight men after adjusting for total energy and fat intake, BMI and other confounding variables. Total fat and monounsaturated fat intakes were positively associated with plasma leptin concentrations even after adjusting for BMI and other confounding variables; however, this association was limited to men of normal weight (BMI<25 kg/m(2)). CONCLUSION: These data suggest that physical activity may be a significantdeterminant of plasma leptin concentrations in men. Increasing physical activity is associated with lower plasma leptin concentrations even after adjusting for BMI. Physical activity may lower leptin concentrations not only due to decreased body fat mass, but potentially through an increase in leptin sensitivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:53:07