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Titolo:
Dose-response effects of zaleplon as compared with triazolam (0.25 mg) andplacebo in chronic primary insomnia
Autore:
Drake, CL; Roehrs, TA; Mangano, RM; Roth, T;
Indirizzi:
Henry Ford Hosp, Sleep Disorders & Res Ctr, Detroit, MI 48202 USA Henry Ford Hosp Detroit MI USA 48202 ers & Res Ctr, Detroit, MI 48202 USA Wyeth Ayerst Res, Clin Res & Dev, Radnor, PA USA Wyeth Ayerst Res Radnor PA USA yerst Res, Clin Res & Dev, Radnor, PA USA
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 8, volume: 15, anno: 2000,
pagine: 595 - 604
SICI:
0885-6222(200012)15:8<595:DEOZAC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHIATRIC-DISORDERS; ZOLPIDEM; EFFICACY; BENZODIAZEPINES; MANAGEMENT; HYPNOTICS; SINGLE; MEMORY;
Keywords:
hypnotics; insomnia; triazolam; zaleplon; sleep; cognitive performance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Drake, CL Henry Ford Hosp, Sleep Disorders & Res Ctr, 2799 W Grand Blvd,CFP3, Detroit, MI 48202 USA Henry Ford Hosp 2799 W Grand Blvd,CFP3 Detroit MIUSA 48202 USA
Citazione:
C.L. Drake et al., "Dose-response effects of zaleplon as compared with triazolam (0.25 mg) andplacebo in chronic primary insomnia", HUM PSYCHOP, 15(8), 2000, pp. 595-604

Abstract

The effects of two nights of treatment with the short-acting benzodiazepine receptor agonist zaleplon, triazolam, or placebo was assessed in chronic primary insomniacs using two concurrent, multi-center, randomized, double-blind. Latin Square crossover studies. Study 1 (n = 47) compared zaleplon (10 and 40 mg) to triazolam (0.25 mg) and placebo. Study 2 (n = 36) compared zaleplon (20 and 60 mg) to triazolam (0.25 mg) and placebo. For each study,polysomnographically recorded sleep parameters and patient reports of sleep quality were collected during baseline and two consecutive nights during the four treatment phases in each study. All doses of zaleplon produced significant decreases in latency to persistent sleep. Although no minimally effective dose could be determined, dose-response effects were apparent. Triazolam 0.25 mg produced a decrease in latency to persistent sleep that was: comparable to that of zaleplon 10 mg. Only the triazolam dose and the 60 mgdose of zaleplon produced significant increases in total sleep time over placebo. Zaleplon 40 and 60 mg and triazolam produced decreases in the percentage of REM sleep compared to placebo. Patient reports of efficacy were consistent with objective findings. In addition, all doses of zaleplon tendedto increase while triazolam decreased the percentage of stage 3/4 sleep. There was no evidence of residual daytime impairment for any of the zaleplondoses, however, triazolam administration produced significant impairment in performance on a digit copying test. A higher number of adverse events were seen with the 40 and 60 mg doses of zaleplon compared to triazolam (0.25) and placebo. At higher doses, zaleplon is more effective than triazolam at reducing latency to persistent sleep in chronic insomnia and is not associated with the decrease in slow-wave sleep or residual impairment observed with triazolam. However increases in total sleep time were apparent only atdoses which produced concomitant increases in the number of adverse events. In contrast, triazolam (0.25 mg) produced increases in total sleep time (similar to 25 min) and decreases in latency to persistent sleep at a dose of 0.25 mg. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:27:06