Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of coronary revascularisation on myocardial blood flow and coronary vasodilator reserve in hibernating myocardium
Autore:
Pagano, D; Fath-Ordoubadi, F; Beatt, KJ; Townend, JN; Bonser, RS; Camici, PG;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Clin Sci Ctr, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Natl Heart & Lung Inst, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland Queen Elizabeth Hosp, Cardiothorac Surg Unit, Birmingham B15 2TH, W Midlands, England Queen Elizabeth Hosp Birmingham W Midlands England B15 2TH lands, England Univ Birmingham, Queen Elizabeth Hosp, Dept Cardiol, Birmingham B15 2TH, WMidlands, England Univ Birmingham Birmingham W Midlands England B15 2TH WMidlands, England
Titolo Testata:
HEART
fascicolo: 2, volume: 85, anno: 2001,
pagine: 208 - 212
SICI:
1355-6037(200102)85:2<208:EOCROM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR DYSFUNCTION; ARTERY DISEASE; STABLE ANGINA; EXERCISE; ISCHEMIA; ECHOCARDIOGRAPHY; PATHOPHYSIOLOGY; ANGIOGRAPHY; MECHANISMS; VIABILITY;
Keywords:
hibernating myocardium; myocardial blood flow; heart failure; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Camici, PG Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Clin Sci Ctr, Du Cane Rd, London W12 0NN, England Univ London ImperialColl Sci Technol & Med Du Cane Rd London England W12 0NN
Citazione:
D. Pagano et al., "Effects of coronary revascularisation on myocardial blood flow and coronary vasodilator reserve in hibernating myocardium", HEART, 85(2), 2001, pp. 208-212

Abstract

Objective-Previous studies have suggested that resting myocardial blood flow is within normal limits in most chronically dysfunctional left ventricular segments which improve function after coronary artery revascularisation (hibernating myocardium). The aim of this study was to assess myocardial blood flow and coronary vasodilator reserve in hibernating myocardium before and after coronary revascularisation. Patients and methods- 30 patients with multivessel coronary disease undergoing coronary revascularisation (21 patients with bypass grafting and nine with coronary angioplasty), and 21 age and sex matched healthy volunteers (controls). Myocardial blood flow (MBF, ml/min/g) was measured by positron emission tomography using oxygen-15 water at rest and after dipyridamole (MBFdip, 0.56 mg/kg in four minutes). Coronary vasodilator reserve was calculated as MBFdip/ MBE Regional wall motion was assessed with echocardiography. Results-Before revascularisation there were 48 remote and 275 dysfunctional myocardial segments, of which 163 (59%) improved function after revascularisation (hibernating). In hibernating segments coronary vasodilator reserve before revascularisation was significantly lower than in remote segments (1.97 (0.7), p < 0.0001) and controls (3.2 (1.5), p < 0.0001). In hibernating segments, myocardial blood flow remained unchanged after revascularisation (0.94 (0.3) nu 0.95 (0.3) ml/min/g, p = 0.3) while coronary vasodilator reserve increased (1.47 (0.7) nu 1.98 (1.0), p < 0.0001). Myocardial blood flow was similar in remote, hibernating segments before and after revascularisation and in controls. Conclusions-This study confirms that myocardial blood flow at rest in hibernating myocardium is within normal limits in most segments, and that hibernating myocardium is characterised by an impaired coronary vasodilator reserve which improves significantly after coronary revascularisation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:24:30