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Titolo:
Lewis phenotypes, leisure time physical activity, and risk of ischaemic heart disease: an 11 year follow up in the Copenhagen male study
Autore:
Hein, HO; Suadicani, P; Gyntelberg, F;
Indirizzi:
Copenhagen Univ Hosp, Copenhagen Male Study Epidemiol Res Unit, DK-2400 Copenhagen NV, Denmark Copenhagen Univ Hosp Copenhagen Denmark NV K-2400 Copenhagen NV, Denmark
Titolo Testata:
HEART
fascicolo: 2, volume: 85, anno: 2001,
pagine: 159 - 164
SICI:
1355-6037(200102)85:2<159:LPLTPA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-RESISTANCE SYNDROME; BLOOD-GROUP; ACTIVITY LEVEL; MEN; SERUM; ASSOCIATION; CHOLESTEROL; WOMEN; LIPOPROTEINS; ANTIGENS;
Keywords:
genetics; ischaemic heart disease; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Hein, HO Copenhagen Univ Hosp, Copenhagen Male Study Epidemiol Res Unit, 23 Bispebjerg Bakke, DK-2400 Copenhagen NV, Denmark Copenhagen Univ Hosp 23 Bispebjerg Bakke Copenhagen Denmark NV k
Citazione:
H.O. Hein et al., "Lewis phenotypes, leisure time physical activity, and risk of ischaemic heart disease: an 11 year follow up in the Copenhagen male study", HEART, 85(2), 2001, pp. 159-164

Abstract

Objective-To test the hypothesis that the predictive value for risk of fatal ischaemic heart disease associated with Lewis phenotypes depends on the level of leisure time physical activity. Design-Prospective study controlling for alcohol, tobacco, serum cotinine,blood pressure, body mass index, serum lipids, work related physical activity, and social class. Setting-The Copenhagen male study, Denmark. Subjects-2826 white men aged 53-75 years without overt cardiovascular disease; 266 (9.4%) had the Le(a-b-) phenotype. Main outcome measure-Incidence of death from ischaemic heart disease during 11 years. Results-107 men died of ischaemic heart disease. Among men with a low level of leisure time physical activity (less than or equal to 4 hours/week moderate or less than or equal to 2 hours/week more vigorous activity), being Le(a-b-) was associated with an increased risk of having a fatal ischaemic heart disease event compared with men with other Lewis phenotypes (relativerisk (RR) 2.7, 95% confidence interval (CI) 1.4 to 5.2; p < 0.01). Among men with a high level of leisure time physical activity, the RR associated with being Le(a-b-) was 1.3 (95% CI 0.5 to 3.1; NS). Compared with all otheralternatives tested, being Le(a-b-) and having a low level of leisure timephysical activity was associated with an RR of 3.2 (95% CI 1.7 to 5.8; p <0.001). As a point estimate and adjusted for confounding variables, among men with low leisure time physical activity the attributable risk associated with Le(a-b-) was 12%-that is, assuming that all sedentary men had phenotypes other than Le(a-b-), 12% of all fatal ischaemic heart disease events would not have occurred. The corresponding point estimate among those more active was 2%. Conclusions-The excess risk of fatal ischaemic heart disease in middle aged and elderly men with the Le(a-b-) phenotype is strongly modified by leisure time physical activity. Public health and clinical implications may be important in populations with a predominantly sedentary lifestyle and in a high proportion of men with the Le(a-b-) phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:50:03