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Titolo:
Homocysteine and coronary heart disease in the Caerphilly cohort: a 10 year follow up
Autore:
Fallon, UB; Ben-Shlomo, Y; Elwood, P; Ubbink, JB; Smith, GD;
Indirizzi:
Univ Bristol, Dept Social Med, Bristol BS8 2PR, Avon, England Univ Bristol Bristol Avon England BS8 2PR Bristol BS8 2PR, Avon, England Llandough Hosp, MRC, Epidemiol Unit, Penarth CF64 2XW, S Glam, Wales Llandough Hosp Penarth S Glam Wales CF64 2XW arth CF64 2XW, S Glam, Wales Univ Pretoria, Dept Chem Pathol, Fac Med, ZA-0001 Pretoria, South Africa Univ Pretoria Pretoria South Africa ZA-0001 -0001 Pretoria, South Africa
Titolo Testata:
HEART
fascicolo: 2, volume: 85, anno: 2001,
pagine: 153 - 158
SICI:
1355-6037(200102)85:2<153:HACHDI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA TOTAL HOMOCYSTEINE; SERUM TOTAL HOMOCYSTEINE; CARDIOVASCULAR-DISEASE; VASCULAR-DISEASE; RISK FACTOR; MYOCARDIAL-INFARCTION; FOLIC-ACID; HOMOCYST(E)INE; STROKE; PHYSICIANS;
Keywords:
homocysteine; coronary heart disease; cohort;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Fallon, UB Univ Bristol, Dept Social Med, Whiteladies Rd,Canynge Hall, Bristol BS8 2PR, Avon, England Univ Bristol Whiteladies Rd,Canynge Hall Bristol Avon England BS8 2PR
Citazione:
U.B. Fallon et al., "Homocysteine and coronary heart disease in the Caerphilly cohort: a 10 year follow up", HEART, 85(2), 2001, pp. 153-158

Abstract

Objective-Prospective assessment of the risk of coronary heart disease associated with total serum homocyst(e)ine (homocysteine) concentration. Design-Nested case-control study. Setting-Caerphilly and surrounding villages in south Wales, UK. Participants-2290 men who participated in phase II of the study in 1984. After a mean follow up of 10 years, 312 men developed coronary heart diseaseand were compared with 1248 randomly selected, age frequency matched controls. Main outcome measure-Acute myocardial infarction or death from coronary heart disease. Results-The geometric mean serum homocysteine concentration was higher in cases (12.2 mu mol/l, 95% confidence interval (CI) 11.8 to 12.6 mu mol/l) than in controls (11.8 mu mol/l, 95% CI 11.3 to 12.5 mu mol/l) (p = 0.09). There was a graded increase in the odds ratio of coronary heart disease across quintiles of the homocysteine concentration distribution compared with the first (p = 0.04), which was attenuated when adjusted for confounding variables (p = 0.4). There was a small but non-significant increase in the adjusted odds ratio of coronary heart disease per standard deviation change inthe log distribution of homocysteine concentration (OR = 1.07 (95% CI .93 to 1.24), p = 0.34). Comparing the top quintile of the homocysteine concentration with the remaining 80%, the adjusted odds ratio of coronary heart disease was 1.03 (95% CI 0.73 to 1.45) (p = 0.8) and comparing the top 5% with the remaining 95% it was 1.05 (95% CI 0.56 to 1.95) (p = 0.9). Conclusions-These findings do not support the hypothesis that a raised homocysteine concentration is a strong independent risk factor for coronary heart disease. Randomised controlled trials of homocysteine lowering treatment such as folic acid are needed before generalising the early positive results of observational studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:37:38