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Titolo:
Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival
Autore:
Xing, LP; Venegas, AM; Chen, A; Garrett-Beal, L; Boyce, BF; Varmus, HE; Schwartzberg, PL;
Indirizzi:
NHGRI, NIH, Bethesda, MD 20892 USA NHGRI Bethesda MD USA 20892NHGRI, NIH, Bethesda, MD 20892 USA Univ Rochester, Dept Pathol, Rochester, NY 14627 USA Univ Rochester Rochester NY USA 14627 ept Pathol, Rochester, NY 14627 USA NCI, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, NIH, Bethesda, MD 20892 USA
Titolo Testata:
GENES & DEVELOPMENT
fascicolo: 2, volume: 15, anno: 2001,
pagine: 241 - 253
SICI:
0890-9369(20010115)15:2<241:GEFARF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-COLON CARCINOMA; STIMULATING FACTOR-I; NF-KAPPA-B; C-SRC; TYROSINE PHOSPHORYLATION; MEDIATED ACTIVATION; OSTEOCLAST FUNCTION; ADHESION KINASE; BONE-RESORPTION; PROTEIN-KINASE;
Keywords:
Src; RANK; osteoclast; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Schwartzberg, PL NHGRI, NIH, Bethesda, MD 20892 USA NHGRI Bethesda MD USA20892 NIH, Bethesda, MD 20892 USA
Citazione:
L.P. Xing et al., "Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival", GENE DEV, 15(2), 2001, pp. 241-253

Abstract

Mutant src(-/-) mice have osteopetrosis resulting from defective osteoclasts, the cells that resorb bone. However, signaling pathways involving Src family members in osteoclasts remain unclear. We demonstrate that expressionof a truncated Src molecule, Src251, lacking the kinase domain, induces osteopetrosis in wild-type and src(+/-) mice and worsens osteopetrosis in src(-/-) mice by a novel mechanism, increased osteoclast apoptosis. Induction of apoptosis by Src251 requires a functional SH2, but not an SH3, domain and is associated with reduced ART kinase activity. Expression of Src251 dramatically reduces osteoclast survival in response to RANKL/TRANCE/OPGL, providing evidence that Src family kinases are required in vivo for survival signaling pathways downstream from TNF family receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:25:27