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Titolo:
Abnormal von Willebrand factor in bleeding angiodysplasias of the digestive tract
Autore:
Veyradier, A; Balian, A; Wolf, M; Giraud, V; Montembault, S; Obert, B; Dagher, I; Chaput, JC; Meyer, D; Naveau, S;
Indirizzi:
Hop Antoine Beclere, Serv Hematol Biol, F-92141 Clamart, France Hop Antoine Beclere Clamart France F-92141 Biol, F-92141 Clamart, France Hop Antoine Beclere, Serv Hepatogastroenterol, F-92141 Clamart, France HopAntoine Beclere Clamart France F-92141 erol, F-92141 Clamart, France Hop Antoine Beclere, Serv Chirurg, Clamart, France Hop Antoine Beclere Clamart France clere, Serv Chirurg, Clamart, France INSERM, U143, F-94275 Le Kremlin Bicetre, France INSERM Le Kremlin Bicetre France F-94275 4275 Le Kremlin Bicetre, France
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 2, volume: 120, anno: 2001,
pagine: 346 - 353
SICI:
0016-5085(200102)120:2<346:AVWFIB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED VONWILLEBRANDS DISEASE; AORTIC-VALVE REPLACEMENT; GASTROINTESTINAL-TRACT; FACTOR MULTIMERS; HEMORRHAGIC TELANGIECTASIA; VASCULAR ECTASIAS; SHEAR-STRESS; FACTOR VWF; STENOSIS; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Meyer, D Hop Antoine Beclere, Serv Hematol Biol, 157 Rue Porte Trivaux, F-92141 Clamart, France Hop Antoine Beclere 157 Rue Porte Trivaux Clamart France F-92141
Citazione:
A. Veyradier et al., "Abnormal von Willebrand factor in bleeding angiodysplasias of the digestive tract", GASTROENTY, 120(2), 2001, pp. 346-353

Abstract

Background & Aims: Involvement of an abnormal von Willebrand factor in thebleeding expression of gastrointestinal angiodysplasias has been suggestedbut not assessed by prospective studies. Methods: To address this issue, 27 patients with either nonbleeding (group A, n = 9) or bleeding (group B, n= 9) digestive angiodysplasias or telangiectasias or diverticular hemorrhage (group C, n = 9) were enrolled. In all patients, an analysis of von Willebrand factor and a screening for the most common disorders associated withan acquired von Willebrand disease were performed. Results: In all patients from groups A and C, von Willebrand factor was normal, and no underlying disease could be found. In contrast, all but 1 patient from group 9 had a variable selective loss of the largest multimeric forms of von Willebrand factor, associated in 7 cases with a stenosis of the aortic valve. Conclusions: This study indicates that most patients with bleeding angiodysplasia or telangiectasia have a deficiency of the largest multimers of von Willebrandfactor induced by a latent acquired von Willebrand disease. Because these multimers ave the most effective in promoting primary hemostasis at the very high shear conditions related to these vascular malformations, we suggestthat their deficiency is likely to contribute to the bleeding diathesis.

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Documento generato il 05/12/20 alle ore 04:31:29