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Titolo:
The molecular chaperone system and other anti-stress mechanisms in archaea
Autore:
Macario, AJL; de Macario, EC;
Indirizzi:
New York State Dept Hlth, Div Mol Med, Wadsworth Ctr, Albany, NY 12201 USANew York State Dept Hlth Albany NY USA 12201 th Ctr, Albany, NY 12201 USA SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY USA SUNY Albany Albany NY USA Sch Publ Hlth, Dept Biomed Sci, Albany, NY USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D262 - D283
SICI:
1093-9946(20010201)6:<D262:TMCSAO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYPEPTIDE-ASSOCIATED COMPLEX; DEVELOPMENTALLY-REGULATED EXPRESSION; METHANOSARCINA-MAZEI S-6; HEAT-SHOCK PROTEINS; TRIGGER FACTOR; METHANOGENIC SUBPOPULATIONS; ESCHERICHIA-COLI; GENE-EXPRESSION; TRANSCRIPTIONAL COACTIVATOR; ANAEROBIC BIOREACTOR;
Keywords:
stress; stressors; protein denaturation; stress proteins; chaperones; cochaperones; protein folding; prefoldin; trigger factor; hop; hip; BAG-1; NAC; multicellular structures; Methanosarcina mazeii; packet; lamina; granular consortium; biofilm; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Macario, AJL New York State Dept Hlth, Div Mol Med, Wadsworth Ctr, Room B-749,POB 509, Albany, NY 12201 USA New York State Dept Hlth Room B-749,POB 509 Albany NY USA 12201
Citazione:
A.J.L. Macario e E.C. de Macario, "The molecular chaperone system and other anti-stress mechanisms in archaea", FRONT BIOSC, 6, 2001, pp. D262-D283

Abstract

This article presents a brief review of stressors, their cellular and intracellular targets, stress proteins, molecular chaperones, and other anti-stress mechanisms. New data are reported on cochaperones and multicellular structures in archaea. The molecular chaperoning systems of bacteria and eukaryotes have been studied for many years and are relatively well known in terms of their components and mechanisms of action, although many details remain to be elucidated and almost certainly other components will be discovered in the future. By comparison, the molecular chaperoning system of archaea is still unexplored. Since archaea have some molecular genetic and physiologic features similar to those of bacteria and some resembling those of eukaryotes, extrapolation from what is known of organisms from these two phylogenetic domains to archaeal species is unwarranted. For example, the components of the molecular chaperone machine, Hsp70( DnaK), Hsp40( DnaJ), and GrpE, in the archaeal species that have it, are closely related to bacterialcounterparts, whereas the archaeal chaperonins are like the eukaryotic equivalents. Furthermore, many archaeal species lack the chaperone machine, incontrast to bacteria and eukaryotes that have it without any known exception. A search for the cochaperones trigger factor, Hop, Hip, BAG-1, and NAC in archaeal genomes demonstrated no conserved equivalents, but two familiesof archaeal molecules were identified that might be related to NAC and Hop, respectively. Multicellular structures with a single species such as packet and lamina are formed by Methanosarcina species, among which the best studied is M. mazeii. Multispecies multicellular structures are formed by a variety of archaeal organisms, which are either flat (biofilm) or globular (granule) and constitute a functional association or consortium. Details of morphology, formation, and internal organization are described for representative examples of multicellular structures. These may be seen as the result of primitive histogenesis reflecting primeval mechanisms of differentiation-development that might have evolved driven by environmental stressors. Cells in these complex threedimensional arrangements are not only positionedso they can interact with each other for more efficient functioning as in a tissue or organ, but are also protected from stressors. Single cells lacking the protective shield of other cells packed together with intercellularconnective material, which is typical of multicellular structures, are directly exposed to environmental stressors and, thus, are at a disadvantage from the evolutionary standpoint. It seems reasonable to argue that differentiation-development leading to histogenesis might have arisen in primeval times as a consequence of the harsh conditions that primitive life forms hadto endure, and that the ability to form tissue-like structures was a primary characteristic that ensured positive selection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:10:14