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Titolo:
Exercise-induced angiogenesis-related growth and transcription factors in skeletal muscle, and their modification in muscle pathology
Autore:
Gustafsson, T; Kraus, WE;
Indirizzi:
Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 acol, S-17177 Stockholm, Sweden Huddinge Univ Hosp, Karolinska Inst, Dept Med Lab Sci & Technol, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 nol, S-14186 Huddinge, Sweden Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC 27710 USA Duke UnivDurham NC USA 27710 Dept Med, Div Cardiol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Cell Biol, Div Cardiol, Durham, NC 27710 USA DukeUniv Durham NC USA 27710 ell Biol, Div Cardiol, Durham, NC 27710 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D75 - D89
SICI:
1093-9946(20010101)6:<D75:EAGATF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HEART-FAILURE; FACTOR MESSENGER-RNA; COLLATERAL VESSEL DEVELOPMENT; INTRAMUSCULAR GENE-TRANSFER; RECEPTOR TYROSINE KINASE; FEMORAL-ARTERY STENOSIS; CAPILLARY GROWTH; NITRIC-OXIDE; SIGNAL-TRANSDUCTION; ENDOTHELIAL-CELLS;
Keywords:
angiogenesis; angiogenic factors; exercise; skeletal muscle; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
161
Recensione:
Indirizzi per estratti:
Indirizzo: Gustafsson, T Karolinska Inst, Dept Physiol & Pharmacol, Berzeliusvag 13, S-17177 Stockholm, Sweden Karolinska Inst Berzeliusvag 13 Stockholm SwedenS-17177 en
Citazione:
T. Gustafsson e W.E. Kraus, "Exercise-induced angiogenesis-related growth and transcription factors in skeletal muscle, and their modification in muscle pathology", FRONT BIOSC, 6, 2001, pp. D75-D89

Abstract

Angiogenesis is the process of formation of new blood vessels; it is generally a rare occurrence in the adult, although it is a common adaptive response to exercise training in skeletal muscle. Current thinking is that angiogenesis is mediated by diffusible angiogenic factors and that the angiogenic activity is regulated through the balance between stimulatory and inhibitory factors. Recent studies have shown that up-regulation of angiogenic factors occurs in response to increased muscle activity in skeletal muscle. The major putative angiogenic factor, vascular endothelial growth factor (VEGF), seems to increase to a greater extent and more consistently than other measured angiogenic factors, such as fibroblast growth factor-2 (FGF-2) andtransforming growth factor-beta (1) (TGF-beta (1)). While the regulating mechanisms in this response are not clear, present data indicate reduced oxygen tension and/or related metabolic alterations in the skeletal muscle as possible stimuli. Data on other angiogenic growth factors are limited, but an increase in endothelial cell-stimulating angiogenic growth factor (ESAF)has been observed in response to increased blood flow and muscle stretching. Therefore, different exercise associated stimuli may all contribute to exercise-induced angiogenesis in skeletal muscle, but possibly through differing angiogenic factors and mechanisms. Understanding these processes is important for the elucidation of mechanisms mediating exercise responsivenessin skeletal muscle, but also for the potential that such understanding might bring to the treatment and prevention of human diseases such as intermittent claudication.

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Documento generato il 25/11/20 alle ore 15:23:44