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Titolo:
Cellular and molecular properties of alpha-dystrobrevin in skeletal muscle
Autore:
Enigk, RE; Maimone, MM;
Indirizzi:
SUNY Upstate Med Univ, Dept Cell & Dev Biol, Syracuse, NY 13210 USA SUNY Upstate Med Univ Syracuse NY USA 13210 Biol, Syracuse, NY 13210 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D53 - D64
SICI:
1093-9946(20010101)6:<D53:CAMPOA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DYSTROPHIN-GLYCOPROTEIN COMPLEX; TORPEDO ELECTRIC ORGAN; NITRIC-OXIDE SYNTHASE; MUSCULAR-DYSTROPHY; NEUROMUSCULAR-JUNCTION; GENOMIC ORGANIZATION; CAENORHABDITIS-ELEGANS; POSTSYNAPTIC PROTEIN; SARCOGLYCAN COMPLEX; BETA-DYSTROBREVIN;
Keywords:
alpha-dystrobrevin; dystrophin-related protein; dystrophin glycoprotein complex; neuromuscular junction; skeletal muscle; sarcolemma; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Maimone, MM SUNY Upstate Med Univ, Dept Cell & Dev Biol, 750 E Adams St, Syracuse, NY 13210 USA SUNY Upstate Med Univ 750 E Adams St Syracuse NY USA 13210 USA
Citazione:
R.E. Enigk e M.M. Maimone, "Cellular and molecular properties of alpha-dystrobrevin in skeletal muscle", FRONT BIOSC, 6, 2001, pp. D53-D64

Abstract

The dystrophin glycoprotein complex (DGC) is a large multisubunit complex located throughout the sarcolemma of striated muscle fibers. This complex is critical for maintaining the structural integrity of muscle fibers duringmuscle contraction and also provides a scaffold for signaling molecules. Defects in some components of the DGC, such as dystrophin and sarcoglycans, disrupt the complex and lead to muscular dystrophies. Alpha-dystrobrevin isa dystrophin-related component of the DGC that is localized to the cytoplasmic side of the sarcolemma. In skeletal muscle, alpha-dystrobrevin is alsohighly concentrated at the neuromuscular junction, a highly specialized region of the sarcolemma responsible for receiving motor nerve signals necessary for muscle contraction. Current evidence suggests that alpha-dystrobrevin plays an important role in signaling at the sarcolemma and in the maturation and maintenance of the postsynaptic apparatus at the neuromuscular junction. In this review, we summarize the currently known cellular and molecular properties of alpha-dystrobrevin in skeletal muscle and discuss its potential functions at both the sarcolemma and neuromuscular junction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 08:54:42