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Titolo:
Skeletal muscle and aging
Autore:
Navarro, A; Lopez-Cepero, JM; del Pino, MJS;
Indirizzi:
Univ Cadiz, Fac Med, Dept Biochem & Mol Biol, Cadiz 11003, Spain Univ Cadiz Cadiz Spain 11003 Dept Biochem & Mol Biol, Cadiz 11003, Spain Univ Cadiz, Fac Med, Dept Cell Biol, Cadiz 11003, Spain Univ Cadiz CadizSpain 11003 Fac Med, Dept Cell Biol, Cadiz 11003, Spain
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D26 - D44
SICI:
1093-9946(20010101)6:<D26:SMAA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-I; NITRIC-OXIDE SYNTHASE; IDIOPATHIC SENILE ANOREXIA; PROTEIN-SYNTHESIS RATE; MITOCHONDRIAL-DNA MUTATIONS; ANTIOXIDANT ENZYME-SYSTEMS; RESPIRATORY-CHAIN FUNCTION; INDUCED OXIDATIVE STRESS; FREE-RADICAL GENERATION; AGE-ASSOCIATED CHANGES;
Keywords:
skeletal muscle; aging; senescence.; mitochondria; free radicals, review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
246
Recensione:
Indirizzi per estratti:
Indirizzo: Navarro, A Univ Cadiz, Fac Med, Dept Biochem & Mol Biol, Plaza 9, Cadiz 11003, Spain Univ Cadiz Plaza 9 Cadiz Spain 11003 aza 9, Cadiz 11003, Spain
Citazione:
A. Navarro et al., "Skeletal muscle and aging", FRONT BIOSC, 6, 2001, pp. D26-D44

Abstract

Age-related changes in muscle mass (sarcopenia) and functional properties are the result of a very complex hierarchical system of basic cell aging processes and cell adaptive responses. A basic aging mechanism pertains to mitochondrial production of free radicals and their associated secondary effects. From this basic aging mechanism many other cellular changes can be explained as direct effects or compensatory changes. Altered skeletal muscle cell biochemical and functional properties during aging resulting from intrinsic mechanisms and from changes in hormonal or local signals that influence phenotype maintenance, are reviewed. The effect of skeletal muscle cell senescence on the cellular response to exercise, and the effect of dietary restriction on muscle cell senescence can also be explored from this perspective.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 19:54:59