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Titolo:
DEVELOPMENTALLY-REGULATED STABILIZATION OF NEURONAL INTERMEDIATE FILAMENTS IN RAT CEREBRAL-CORTEX
Autore:
GIASSON BI; MUSHYNSKI WE;
Indirizzi:
MCGILL UNIV,DEPT BIOCHEM,3655 DRUMMOND ST MONTREAL PQ H3G 1Y6 CANADA MCGILL UNIV,DEPT BIOCHEM MONTREAL PQ H3G 1Y6 CANADA
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 229, anno: 1997,
pagine: 77 - 80
SICI:
0304-3940(1997)229:2<77:DSONIF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN NF-L; NERVOUS-SYSTEM; NEUROFILAMENT PROTEINS; ALPHA-INTERNEXIN; EXPRESSION; POLYPEPTIDES; CELLS;
Keywords:
ALPHA-INTERNEXIN; CEREBRAL CORTEX; DEVELOPMENT; NEUROFILAMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
B.I. Giasson e W.E. Mushynski, "DEVELOPMENTALLY-REGULATED STABILIZATION OF NEURONAL INTERMEDIATE FILAMENTS IN RAT CEREBRAL-CORTEX", Neuroscience letters, 229(2), 1997, pp. 77-80

Abstract

The expression and Triton X-100 (Triton) solubility of neuronal intermediate filament proteins were determined in the developing rat cerebral cortex. The level of expression of alpha-internexin was unchanged from embryonic day 15 (E15) to postnatal day 15 (P15), whereas expression of the mid-sized neurofilament subunit increased continually duringthis interval concomitant with a reduction in Triton solubility of the two proteins. The low molecular weight neurofilament subunit, first barely detected at P2, was largely insoluble in Triton from the initial time point that its solubility could be assayed, at P5, to P15. Similar expression patterns and Triton solubility profiles were obtained for neuronal intermediate filament proteins in cultured neurons from E15 cerebral cortex. These results suggest that alpha-internexin is expressed earlier than neurofilament proteins to provide a more plastic network in the early developing brain. The incorporation of neurofilament proteins apparently results in the formation of the more stable intermediate filament network found in mature neurons. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:32:46