Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Coexistence of zinc and iron augmented oxidative injuries in the nigrostriatal dopaminergic system of SD rats
Autore:
Lin, AMY;
Indirizzi:
Vet Gen Hosp Taipei, Dept Med Res & Educ, Taipei, Taiwan Vet Gen Hosp Taipei Taipei Taiwan , Dept Med Res & Educ, Taipei, Taiwan Natl Yang Ming Univ, Dept Physiol, Taipei 112, Taiwan Natl Yang Ming UnivTaipei Taiwan 112 , Dept Physiol, Taipei 112, Taiwan
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 3, volume: 30, anno: 2001,
pagine: 225 - 231
SICI:
0891-5849(20010201)30:3<225:COZAIA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID-PEROXIDATION; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; NEURONAL DEATH; FREE-RADICALS; BRAIN; ANTIOXIDANT; ALUMINUM; STIMULATION; GLUTATHIONE;
Keywords:
zinc; iron; oxidative stress; substantia nigra; striatum; neurodegeneration; free radicals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, AMY Vet Gen Hosp Taipei, Dept Med Res & Educ, Taipei, Taiwan Vet Gen Hosp Taipei Taipei Taiwan d Res & Educ, Taipei, Taiwan
Citazione:
A.M.Y. Lin, "Coexistence of zinc and iron augmented oxidative injuries in the nigrostriatal dopaminergic system of SD rats", FREE RAD B, 30(3), 2001, pp. 225-231

Abstract

Clinical studies have demonstrated an excess of transition metals, including zinc and iron, in the substantia nigra (SN) of Parkinson's patients. In the present study, the neurotoxic effect of zinc was investigated using iron as a positive control. Addition of zinc or iron to brain homogenates increased lipid peroxidation. Zinc was less potent than iron in inducing lipid peroxidation. Coincubation with desferrioxamine prevented zinc- and iron-induced lipid peroxidation . Furthermore, glutathione (GSH), S-nitroso-N-acetylpenicillamine, or melatonin inhibited zinc-induced lipid peroxidation. The oxidative effect of zinc was further investigated in anesthetized rats. Seven days after intranigral infusion of zinc, lipid peroxidation was elevated in the infused SN, and dopamine content and tyrosine hydroxylasepositiveaxons were decreased in the ipsilateral striatum. Zinc was less potent than iron in inducing neurodegeneration in vivo. L-Buthionine-[S,R]-sulfoximine pretreatment (i.c.v.), which depletes cellular GSH levels, enhanced zinc induced oxidative injuries in the nigrostriatal doparninergic system. Moreover, simultaneous infusion of zinc and iron appeared to augment oxidative injuries in rat brain. Taken together, our results demonstrate that intranigral infusion of zinc caused degeneration of the nigrostriatal dopaminergic system in rat brain. Furthermore, coexistence of zinc and iron augmented oxidative injuries in rat brain. These findings indicate that both zinc and iron contribute to the etiology of Parkinsonism. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:16:09