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Titolo:
Vaccination against ovine footrot using a live bacterial vector to deliverbasic protease antigen
Autore:
Moore, RJ; Stewart, DJ; Lund, K; Hodgson, ALM;
Indirizzi:
CSIRO, Div Anim Hlth, Anim Hlth Res Lab, Parkville, Vic 3052, Australia CSIRO Parkville Vic Australia 3052 es Lab, Parkville, Vic 3052, Australia
Titolo Testata:
FEMS MICROBIOLOGY LETTERS
fascicolo: 2, volume: 194, anno: 2001,
pagine: 193 - 196
SICI:
0378-1097(20010115)194:2<193:VAOFUA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORYNEBACTERIUM-PSEUDOTUBERCULOSIS; BACTEROIDES-NODOSUS; PROTECTIVE IMMUNITY; RECOMBINANT; RESPONSES; VACCINES; ANTIBODY; STRAINS; SHEEP; PILUS;
Keywords:
footrot; vaccine vector; basic protease; Corynebacterium pseudotuberculosis; Dichelobacter nodosus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Moore, RJ CSIRO, Australian Anim Hlth Lab, Private Bag 24, Geelong, Vic 3220, Australia CSIRO Private Bag 24 Geelong Vic Australia 3220 3220, Australia
Citazione:
R.J. Moore et al., "Vaccination against ovine footrot using a live bacterial vector to deliverbasic protease antigen", FEMS MICROB, 194(2), 2001, pp. 193-196

Abstract

A strain of Corynebacterium pseudotuberculosis, designated Terminus, that has been rationally attenuated by deletion of the phospholipase D gene, is being developed as a live vaccine vector fur the delivery of veterinary vaccine antigens. In the present study a recombinant form of the basic protease gene of the ovine footrot causative bacterium, Dichelobacter nodosus, wasintroduced into the vector strain using the high copy number plasmid pEP2. This strain secreted the basic protease protein. Vaccination trials in sheep with the recombinant strain demonstrated that, although an IgG immune response was elicited, the animals were not protected from footrot following artificial challenge under pen conditions. Although the sheep were not protected there was evidence that the progression of the disease was slowed. (C) 2001 Federation of European Microbiological Societies. published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:05:25