Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Immunotherapy in atopic dermatitis
Autore:
Mastrandrea, F;
Indirizzi:
AOSS Annunziata, Allergy & Clin Immunol Ctr, I-74100 Taranto, Italy AOSS Annunziata Taranto Italy I-74100 mmunol Ctr, I-74100 Taranto, Italy
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 1, volume: 10, anno: 2001,
pagine: 49 - 63
SICI:
1354-3784(200101)10:1<49:IIAD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL RESPONSES; DEVELOPMENTALLY-REGULATED EXPRESSION; LYMPHOCYTE-ASSOCIATED ANTIGEN; INTERFERON-GAMMA-THERAPY; PLACEBO-CONTROLLED TRIAL; NATURAL-KILLER-CELLS; DOUBLE-BLIND; DERMATOPHAGOIDES-PTERONYSSINUS; SUBLINGUAL IMMUNOTHERAPY; ALLERGEN IMMUNOTHERAPY;
Keywords:
atopic inflammation; allergy; atopic dermatitis; IFN-gamma; IL 12; immunotherapy; haemopoietic precursors; pathogenesis; skin-homing lymphocytes; Tdt; T-cell ontogeny; Th1; Th2; treatment;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
142
Recensione:
Indirizzi per estratti:
Indirizzo: Mastrandrea, F AOSS Annunziata, Allergy & Clin Immunol Ctr, Via Bruno, I-74100 Taranto, Italy AOSS Annunziata Via Bruno Taranto Italy I-74100 nto, Italy
Citazione:
F. Mastrandrea, "Immunotherapy in atopic dermatitis", EXPERT OP I, 10(1), 2001, pp. 49-63

Abstract

Atopic denmatitis (AD) is a common inflammatory disease involving the skinand often other organs and systems, mainly respiratory. A definitive general consensus on the AD pathogenesis has not yet been established, however several lines of evidence suggest that T-cells play a crucial role in priming AD early-stage lesions. Main topics involved in the disease pathogenesis have been reviewed, which considered the concept of local and systemic haemopoietic events as important contributors to allergic inflammation, a concept now achieving great acceptance. The recently recognised atopic nature ofthe skin inflammation in AD has raised increasing interest for treatment with allergen-specific immunotherapy. However, we only found eight studies using specific immunotherapy (SIT) in AD, two double-blind, placebo-controlled (DBPC) and six observational. One controlled and five observational reported favourable outcomes. The one unique study providing negative results was flawed by the ineffective oral route of extract administration. Despite being encouraging, the reported results do not allow definitive conclusionsbased on meta-analytic techniques because the amount and quality of information in the literature is not sufficient. The highly promising sub-lingualimmunotherapy (SLIT) is discussed with its potential capability of controlling not only the skin lesion severity but also its capability of preventing the development of atopic dermatitis into asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 05:36:40