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Titolo:
The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion
Autore:
Singh, N; Talalayeva, Y; Tsiper, M; Romanov, V; Dranovsky, A; Colflesh, D; Rudamen, G; Vitek, MP; Shen, J; Yang, XD; Goldgaber, D; Schwarzman, AL;
Indirizzi:
SUNY Stony Brook, Dept Psychiat, HSC, Stony Brook, NY 11794 USA SUNY StonyBrook Stony Brook NY USA 11794 HSC, Stony Brook, NY 11794 USA SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 Med, Stony Brook, NY 11794 USA SUNY Stony Brook, UMIC, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 UMIC, Stony Brook, NY 11794 USA Duke Univ, Med Ctr, Dept Neurol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Neurol, Durham, NC 27710 USA Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 eurol Dis, Boston, MA 02115 USA
Titolo Testata:
EXPERIMENTAL CELL RESEARCH
fascicolo: 1, volume: 263, anno: 2001,
pagine: 1 - 13
SICI:
0014-4827(20010201)263:1<1:TROADP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; LONG-TERM POTENTIATION; BETA-CATENIN; HIPPOCAMPAL-NEURONS; CAENORHABDITIS-ELEGANS; ENDOPLASMIC-RETICULUM; LINKED PRESENILIN-1; MEMBRANE TOPOLOGY; TRANSGENIC MICE; MOLECULE L1;
Keywords:
Alzheimer's disease; presenilin 1; cell-cell adhesion; epithelial cells; primary neuronal cultures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Schwarzman, AL SUNY Stony Brook, Dept Psychiat, HSC, T-10, Stony Brook, NY11794 USA SUNY Stony Brook T-10 Stony Brook NY USA 11794 NY 11794 USA
Citazione:
N. Singh et al., "The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion", EXP CELL RE, 263(1), 2001, pp. 1-13

Abstract

Most cases of familial early-onset Alzheimer's disease are caused by mutations in the presenilin 1 (PS1) gene. However, the cellular functions of PS1are unknown. We showed predominant localization of PS1 to cell-cell contacts of the plasma membrane in human prostate epithelial tissue and in a human epithelial cell fine HEp2 stably transfected with an inducible PS1 construct, PS1 co-immunoprecipitated with beta -catenin from cell lysates of stable transfectants, Conversely, PS1 lacking the PS1-beta -catenin interactionsite did not co-immunoprecipitate with beta -catenin and was not recruitedto the cell-cell contacts. L cells, which do not form tight intercellular contacts, formed clusters of adhered cells after stable transfection with GFP-PS1 cDNA and demonstrated a clear preference for independent aggregationin the mixed cultures. However, L cells transfected with mutant GFP-PS1 constructs, which had a truncated N-terminus of PS1 or deleted PS1-beta -catenin interaction site, failed to form intercellular contacts. In addition, in primary cultures of mouse cortical neurons PS1 was highly concentrated onthe surface of extended growth cones. Taken together, our results suggest an important role of PS1 in intercellular adhesion in epithelial cells and neurons. (C) 2001 Academic Press.

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Documento generato il 06/04/20 alle ore 22:23:49