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Titolo:
Monoanionic N,N,O-scorpionate ligands and their iron(II) and zinc(II) complexes: Models for mononuclear active sites of non-heme iron oxidases and zinc enzymes
Autore:
Beck, A; Weibert, B; Burzlaff, N;
Indirizzi:
Univ Konstanz, Fachbereich Chem, D-78457 Constance, Germany Univ KonstanzConstance Germany D-78457 Chem, D-78457 Constance, Germany
Titolo Testata:
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
fascicolo: 2, , anno: 2001,
pagine: 521 - 527
SICI:
1434-1948(200102):2<521:MNLATI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISOPENICILLIN-N-SYNTHASE; DIOXYGEN BINDING-SITES; CARBONIC-ANHYDRASE; CATECHOL DIOXYGENASES; REVERSIBLE FORMATION; HYDROXIDE COMPLEX; FERROUS COMPLEXES; CRYSTAL-STRUCTURE; FUNCTIONAL-MODEL; NONHEME;
Keywords:
scorpionates; zinc; iron; oxidases; enzymes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Burzlaff, N Univ Konstanz, Fachbereich Chem, Univ Str 10,Fach M728, D-78457 Constance,Germany Univ Konstanz Univ Str 10,Fach M728 Constance Germany D-78457
Citazione:
A. Beck et al., "Monoanionic N,N,O-scorpionate ligands and their iron(II) and zinc(II) complexes: Models for mononuclear active sites of non-heme iron oxidases and zinc enzymes", EUR J INORG, (2), 2001, pp. 521-527

Abstract

The chemical behavior of two bis(3,5-dialkylpyrazol-1-yl)acetic acids and their coordination properties towards ZnCl2 and Fe Cl-2 was studied. Reaction of bis(3,5-dimethylpyrazol-1-yl)acetic acid (bdmpza) (1) with ZnCl2 and FeCl2 gave the 2:1 complexes [(bdmpza)(2)Zn] (4) and [(bdmpza)(2)Fe] (5). Crystal structures of both complexes were obtained. In contrast, the sterically more hindered ligand bis(3,5-di-tert-butylpyrazol-1-yl)acetic acid (bdtbpza) (3) coordinates only once to zinc(II) resulting in the complex I(bdtbpza)ZnCl] (6). This provides a structural model complex for the active sites of zinc enzymes such as thermolysin or carboxypeptidase. The good agreement with these active sites was demonstrated by a crystal structure of 6. Tothe best of our knowledge, this is the first report of zinc complexes witha monoanionic N,N,O-tridentate ligand using a carboxylate O-donor. Substitution of benzylthiolate for the chloride ligand 6 yielded [(bdtbpza)Zn(SCH2Ph)] (8) indicating that the bulky tert-butyl groups do not prevent access to the zinc atom. Reaction of bdtbpza (3) with FeCl2 led to [(bdtbpza)FeCl](7), which might serve as a structural model complex for the active sites of mononuclear non-heme iron oxidases and oxygenases such as IPNS, DAOCS orGAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 08:11:10