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Titolo:
The plasminogen activator inhibitor (PAI)-1 promoter 4G/4G genotype is notassociated with ischemic stroke in a population of German children
Autore:
Nowak-Gottl, U; Strater, R; Kosch, A; von Eckardstein, A; Schobess, R; Luigs, P; Nabel, P; Vielhaber, H; Kurnik, K; Junker, R;
Indirizzi:
Univ Hosp Munster, Munster, Germany Univ Hosp Munster Munster GermanyUniv Hosp Munster, Munster, Germany Univ Munster, Inst Clin Chem & Lab Med, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 m & Lab Med, D-4400 Munster, Germany Univ Munster, Inst Arteriosclerosis Res, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 lerosis Res, D-4400 Munster, Germany Univ Hosp Halle Saale, Halle, Germany Univ Hosp Halle Saale Halle Germany iv Hosp Halle Saale, Halle, Germany Lachnerstr Childrens Hosp, Dept Paediat, Munich, Germany Lachnerstr Childrens Hosp Munich Germany Dept Paediat, Munich, Germany Univ Hosp Munich, Dept Paediat, Munich, Germany Univ Hosp Munich Munich Germany p Munich, Dept Paediat, Munich, Germany
Titolo Testata:
EUROPEAN JOURNAL OF HAEMATOLOGY
fascicolo: 1, volume: 66, anno: 2001,
pagine: 57 - 62
SICI:
0902-4441(200101)66:1<57:TPAI(P>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-V-LEIDEN; CEREBROVASCULAR-DISEASE; PAI-1 GENE; METHYLENETETRAHYDROFOLATE REDUCTASE; MYOCARDIAL-INFARCTION; 4G/5G POLYMORPHISM; VENOUS THROMBOSIS; PROTHROMBIN GENE; RISK FACTOR; YOUNG-PATIENTS;
Keywords:
childhood stroke; factor V G1691A; prothrombin G20210A; MTHFR C677T; lipoprotein (a);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Nowak-Gottl, U Univ Munster, Dept Paediat Haematol & Oncol, Albert Schweitzer Str 33, D-48149 Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48149
Citazione:
U. Nowak-Gottl et al., "The plasminogen activator inhibitor (PAI)-1 promoter 4G/4G genotype is notassociated with ischemic stroke in a population of German children", EUR J HAEMA, 66(1), 2001, pp. 57-62

Abstract

Objectives: To investigate the relationship between an insertion/deletion (4G/5G) polymorphism of the plasminogen activator inhibitor (PAI)-1 gene and childhood patients with a past history of ischemic stroke. Methods: The PAI-1 4G/4G genotype and the coinheritance with lipoprotein (Lp) (a) levels,the factor V (FV) G1691A mutation, the prothrombin (PT) G20210A variant, and the methylenetetrahydrofolate reductase (MTHFR) T677T genotype were studied in 198 Caucasian children with stroke and 951 controls (same age, sex and ethnical distribution). In a randomly selected subgroup of patients/controls (n = 60) PAI-1 activities have been investigated. Results: The distribution of the 4G/5G genotypes was no different in childhood stroke patients and controls, with a 4G allele frequency of 55.8% in patients compared with53.8% in control subjects (P = 0.49). The 4G/4G genotype compared with theremaining genotypes was present in 43 cases and 167 (17.6% vs. 21.7%; OR/CI: 1.30/0.89-1.98; P = 0.3). PAI-1 activity was significantly elevated (P <0.001) in the patient group. Conclusions: Data presented here suggest thatthe 4G/4G genotype is not a major risk factor in the aetiology of childhood ischemic stroke.

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Documento generato il 25/09/20 alle ore 22:49:35