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Titolo:
A high serum-soluble interleukin-2 receptor level is associated with a poor outcome of aggressive non-Hodgkin's lymphoma
Autore:
Niitsu, N; Iijima, K; Chizuka, A;
Indirizzi:
Toho Univ, Sch Med, Dept Internal Med 1, Tokyo, Japan Toho Univ Tokyo Japan Univ, Sch Med, Dept Internal Med 1, Tokyo, Japan
Titolo Testata:
EUROPEAN JOURNAL OF HAEMATOLOGY
fascicolo: 1, volume: 66, anno: 2001,
pagine: 24 - 30
SICI:
0902-4441(200101)66:1<24:AHSIRL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; PROGNOSTIC VALUE; CELL LYMPHOMA; IL-2 RECEPTOR; DISEASE; GRADE; EXPRESSION; LEUKEMIA; PROTEIN;
Keywords:
soluble interleukin-2 receptor; aggressive non-Hodgkin's lymphoma International Prognostic Index; prognostic factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Niitsu, N 1-8-12-S1307 Omori Honcho,Ota Ku, Tokyo 1430011, Japan 1-8-12-S1307 Omori Honcho,Ota Ku Tokyo Japan 1430011 11, Japan
Citazione:
N. Niitsu et al., "A high serum-soluble interleukin-2 receptor level is associated with a poor outcome of aggressive non-Hodgkin's lymphoma", EUR J HAEMA, 66(1), 2001, pp. 24-30

Abstract

Soluble interleukin-2 receptor (sIL-2R) is produced by activated T and B cells, and the level of this receptor is elevated in patients with non-Hodgkin's lymphoma (NHL). The present study demonstrated that the sIL-2R level was high in the following groups of patients with aggressive NHL; those agedgreater than or equal to 60 yr, those with a poor PS, those in Ann Arbor stage III or IV, and those in the high-intermediate or high risk group according to the International Prognostic Index (IPI). Overall survival was significantly poorer when the sIL-2R level was 2000 U/ml or more. In addition, the overall survival of patients in the low (L) and low-intermediate (L-I) risk groups with an sIL-2R level of 3000 U/ml or more was significantly poorer, suggesting that the sIL-2R level could be particularly useful for identifying patients with a poor prognosis among the L and L-I risk groups. Univariate analysis identified some significant prognostic factors, and multivariate analysis of these factors plus the five IPI prognostic factors showed that the sIL-2R level was an independent prognostic indicator. In conclusion, the present findings established that the sIL-2R level is a significant independent prognostic factor in patients with aggressive NHL.

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Documento generato il 05/04/20 alle ore 06:31:24