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Titolo:
4-hydroxy-2 ',4 ',6 '-trichlorobiphenyl and 4-hydroxy-2 ',3 ',4 ',5 '-tetrachlorobiphenyl are estrogenic in rainbow trout
Autore:
Carlson, DB; Williams, DE;
Indirizzi:
Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR 97331 USA Oregon State Univ Corvallis OR USA 97331 Toxicol, Corvallis, OR 97331 USA Oregon State Univ, Marine Freshwater Biomed Sci Ctr, Corvallis, OR 97331 USA Oregon State Univ Corvallis OR USA 97331 Sci Ctr, Corvallis, OR 97331 USA
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
fascicolo: 2, volume: 20, anno: 2001,
pagine: 351 - 358
SICI:
0730-7268(200102)20:2<351:4'''A4>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCHLORINATED-BIPHENYLS PCBS; SALMO-GAIRDNERI; GREAT-LAKES; IN-VITRO; VITELLOGENIN; INDUCTION; CONGENERS; 2,2',4,4',5,5'-HEXACHLOROBIPHENYL; CONTAMINATION; PESTICIDES;
Keywords:
hydroxylated polychlorinated biphenyls; mixtures; vitellogenin; trout; endocrine disruption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, DE Oregon State Univ, Dept Environm & Mol Toxicol, Corvallis, OR97331 USA Oregon State Univ Corvallis OR USA 97331 allis, OR 97331 USA
Citazione:
D.B. Carlson e D.E. Williams, "4-hydroxy-2 ',4 ',6 '-trichlorobiphenyl and 4-hydroxy-2 ',3 ',4 ',5 '-tetrachlorobiphenyl are estrogenic in rainbow trout", ENV TOX CH, 20(2), 2001, pp. 351-358

Abstract

Many natural and synthetic xenobiotics are known to interact with endocrine systems of animals. Various hydroxylated metabolites of persistent polychlorinated biphenyl contaminants (hydroxy-polychlorinated biphenyls [OH-PCBs]) have been shown to have agonist or antagonist interactions with estrogenreceptors (ERs). In this study, 4-hydroxy-2',4',6'-trichlorobiphenyl (ON PCB 30) and 4-hydroxy-2',3',4',5'-tetrachlorobipheny (OH-PCB 61), and the natural estrogens 17 beta -estradiol (E-2) and estrone (E-1), were incorporated into diet and fed to juvenile rainbow trout. The production of vitellogenin (VTG), an egg yolk protein precursor in oviparous animals, was used as a marker of hepatic ER binding. All compounds induced plasma VTG in a dose-dependent manner, with maximal levels of approximately 5 mg VTG/ml plasma induced by E-2, E-1, and OH-PCB 30. Maximum plasma VTG of 0.048 mg/ml in thehighest dose (50 mg/kg) of OH-PCB 61 was approximately 100-fold lower thannatural estrogens and OH-PCB 30. At doses that induced submaximal VTG, E-1was two- to threefold less potent, and OH-PCBs were up to 500-fold less potent, than E-2. Sex differences in VTG synthesis were apparent at weakly estrogenic doses, but not at maximal VTG-inducing doses. Predictions from previous receptor-binding studies underestimated the maximum estrogenic response of OH-PCB 30 in trout, which was achieved with a dose 10 times higher than E-2. Differences in plasma VTG induction by OH-PCB 30 and OH-PCB 61 support in vitro predictions that the degree and position of chlorination are important for ER activation. Neither mixtures of estrogens nor OH-PCBs resulted in synergistic VTG induction.

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Documento generato il 25/11/20 alle ore 01:32:55