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Titolo:
Effect of 2,4-dichlorophenoxyacetic acid herbicide on Escherichia coli growth, chemical composition, and cellular envelope
Autore:
Balague, C; Sturtz, N; Duffard, R; de Duffard, AME;
Indirizzi:
Univ Nacl Rosario, Fac Biochem & Pharmaceut Sci, Expt Toxicol Lab, RA-2000Rosario, Santa Fe, Argentina Univ Nacl Rosario Rosario Santa Fe Argentina RA-2000 Santa Fe, Argentina
Titolo Testata:
ENVIRONMENTAL TOXICOLOGY
fascicolo: 1, volume: 16, anno: 2001,
pagine: 43 - 53
SICI:
1520-4081(200102)16:1<43:EO2AHO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE HYDROPHOBICITY; POLYACRYLAMIDE GELS; HUMAN-ERYTHROCYTES; VIRULENCE FACTORS; RHIZOBIUM SP; CELLS; RESISTANCE; TETRACYCLINE; SALICYLATE; EXPRESSION;
Keywords:
2,4-D; uropathogenic Escherichia coli; fimbriae; hydrophobicity; lipoperoxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: de Duffard, AME Univ Nacl Rosario, Fac Biochem & Pharmaceut Sci, Expt Toxicol Lab, Suipacha 570, RA-2000 Rosario, Santa Fe, Argentina Univ Nacl Rosario Suipacha 570 Rosario Santa Fe Argentina RA-2000
Citazione:
C. Balague et al., "Effect of 2,4-dichlorophenoxyacetic acid herbicide on Escherichia coli growth, chemical composition, and cellular envelope", ENVIRON TOX, 16(1), 2001, pp. 43-53

Abstract

2,4-Dichlorophenoxyacetic acid (2,4-D) is a herbicide widely used in the world and mainly excreted by the renal route in exposed humans and animals. Herbicides can affect other nontarget organisms, such as Escherichia coli We observed that a single exposure to 1 mM 2,4-D diminished growth and totalprotein content in all E. coli strains tested in vitro. In addition, successive exposures to 0.01 mM 2,4-D had a toxic effect decreasing growth up toearly stationary phase. Uropathogenic E. coli adhere to epithelial cells mediated by fimbriae, adhesins, and hydrophobic properties. 2,4-D exposure of uropathogenic E. coli demonstrated altered hydrophobicity and fimbriation. Hydrophobicity index values obtained by partition in p-xylene/water were 300-420% higher in exposed cells than in control ones. Furthermore, values of hemagglutination titer, protein contents in fimbrial crude extract, and electron microscopy demonstrated a significant diminution of fimbriation intreated cells. Other envelope alterations could be detected, such as lipoperoxidation, evidenced by decreased polyunsaturated fatty acids and increased lipid degradation products (malonaldehyde), and motility diminution. These alterations decreased cell adherence to erythrocytes, indicating a diminished pathogenic capacity of the 2,4-D-exposed E. coli. (C) 2001 by John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:31:45