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Titolo:
The immuno-inflammatory mechanism for tissue injury in inflammatory bowel disease and Helicobacter pylori-infected chronic active gastritis - Roles of the mucosal immune system
Autore:
Nagura, H; Ohtani, H; Sasano, H; Matsumoto, T;
Indirizzi:
Tohoku Univ, Grad Sch Med Sci, Dept Pathol, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Ku, Sendai, Miyagi 9808575, Japan Osaka City Univ, Sch Med, Dept Internal Med, Osaka 545, Japan Osaka City Univ Osaka Japan 545 Med, Dept Internal Med, Osaka 545, Japan
Titolo Testata:
DIGESTION
, volume: 63, anno: 2001, supplemento:, 1
pagine: 12 - 21
SICI:
0012-2823(2001)63:<12:TIMFTI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEYERS-PATCHES; CELLS; EXPRESSION; SPECIALIZATION; MOLECULES; COLON;
Keywords:
inflammatory bowel disease; Helicobacter pylori; chronic active gastritis; mucosal immune system; mucosal barrier; pro-inflammatory cytokine; antigen presentation; neutrophil; macrophage; secretory IgA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Nagura, H Tohoku Univ, Grad Sch Med Sci, Dept Pathol, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan Tohoku Univ 2-1 Seiryo Machi Sendai Miyagi Japan 9808575 , Japan
Citazione:
H. Nagura et al., "The immuno-inflammatory mechanism for tissue injury in inflammatory bowel disease and Helicobacter pylori-infected chronic active gastritis - Roles of the mucosal immune system", DIGESTION, 63, 2001, pp. 12-21

Abstract

The gastrointestinal mucosa is exposed to myriads of infectious and food antigens, and a unique barrier mechanism handles them on the mucosal surface, and specific immune responses to these antigens call on the mucosal immune system in the mucosal tissues to maintain homeostasis of gastrointestinalfunctions and structure. Abrogation of these mucosal defense mechanisms may lead to alter immunologic homeostasis in the gastrointestinal tract and to induce pathological features of inflammatory bowel disease (IBD) and Helicobacter pylori-infected chronic active gastritis, including chronic activeinflammation, mucosal atrophy and tissue injuries. Regardless of the initiating cause of these long-standing chronic active mucosal inflammations, characteristic immuno-inflammatory mechanisms are involved in their pathogenesis, that is, similar and/or different specific prolonged impaired and excessive immuno-inflammatory responses following the abrogation of the mucosalbarrier system are present in the diseased mucosa with IBD and H. pylori infection, respectively. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:06:01