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Titolo:
Cytology and immunophenotyping of low- and intermediate-grade B-Cell non-Hodgkin's lymphomas with a predominant small-cell component: A study of 56 cases
Autore:
Chhieng, DC; Cohen, JM; Cangiarella, JF;
Indirizzi:
Univ Alabama, Dept Pathol, Birmingham, AL 35249 USA Univ Alabama Birmingham AL USA 35249 ept Pathol, Birmingham, AL 35249 USA
Titolo Testata:
DIAGNOSTIC CYTOPATHOLOGY
fascicolo: 2, volume: 24, anno: 2001,
pagine: 90 - 97
SICI:
8755-1039(200102)24:2<90:CAIOLA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FINE-NEEDLE ASPIRATION; CHRONIC LYMPHOCYTIC-LEUKEMIA; MALIGNANT-LYMPHOMA; FLOW-CYTOMETRY; DIAGNOSIS; CLASSIFICATION; BIOPSY; NODES; SPECIMENS;
Keywords:
needle biopsy; cytology; follicular center lymphoma; mantle-cell lymphoma; small lymphocytic lymphoma; lymphoma classification; immunophenotyping;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Chhieng, DC Univ Alabama, Dept Pathol, KB 526,61919 St S, Birmingham, AL 35249 USA Univ Alabama KB 526,61919 St S Birmingham AL USA 35249 249 USA
Citazione:
D.C. Chhieng et al., "Cytology and immunophenotyping of low- and intermediate-grade B-Cell non-Hodgkin's lymphomas with a predominant small-cell component: A study of 56 cases", DIAGN CYTOP, 24(2), 2001, pp. 90-97

Abstract

Diagnosis of non-Hodgins's lymphomas based on cytologic evaluation of fine-needle aspirates and body cavity fluids has gained increasing acceptance. However, the accurate diagnosis and classification of low- and intermediate-grade B-cell lymphomas with a predominant small-cell population still present a diagnostic challenge. In this study, we reviewed the cytology and immunopheno type of 56 cases of low- and intermediate-grade non-Hodgkin's B-cell lymphomas composed of predominantly small cells, with histologic correlation in all cases. These cases consisted of 23 small lymphocytic lymphomas (SLL), 15 follicular center lymphomas (FCL), grade I (small cell predominant), 8 lymphoplasmacytoid lymphomas (LPL), 6 mantle-cell lymphomas (MCL), and 4 marginal zone lymphomas (MZL) including mucosa-associated lymphoid tissue (MALT) lymphoma. Histologic comparison was available in all cases. A cytologic diagnosis of malignant lymphoma was made in 46 (82%) cases. Based oncytomorphology and immunophenotyping of cytologic material, 39 (85%) caseswere correctly classified using the Revised European and American Lymphomaclassification. In 7 (11%) cases, which included 3 FCLs, 2 MALT lymphomas,and 2 SLLs, the findings were atypical but not diagnostic of lymphoma. There were 3 (5%) false-negative cases. They were 2 SLLs and a FCL. Immunophenotyping done in 4 "atypical" cases was noncontributory. No marker studies were done in the remaining "atypical" case and all false-negative cases. We conclude that cytology, when used in conjunction with immunophenotyping, can accurately diagnose and in most instances subclassify low- and intermediate-grade B-cell non-Hodgkin's lymphoma with a predominant small-cell population. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:07:57