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Titolo:
Cardiovascular risk factors and LDL subfraction profile in Type 2 diabetesmellitus subjects with good glycaemic control
Autore:
Tan, CE; Chew, LS; Chio, LF; Tai, ES; Lim, HS; Lim, SC; Jayakumar, L; Eng, HK; Packard, CJ;
Indirizzi:
Singapore Gen Hosp, Dept Endocrinol, Singapore 169608, Singapore SingaporeGen Hosp Singapore Singapore 169608 ingapore 169608, Singapore Singapore Gen Hosp, Dept Biochem, Singapore 169608, Singapore Singapore Gen Hosp Singapore Singapore 169608 ingapore 169608, Singapore Alexandra Hosp, Dept Med, Singapore 159964, Singapore Alexandra Hosp Singapore Singapore 159964 d, Singapore 159964, Singapore Glasgow Royal Infirm, Dept Pathol Biochem, Glasgow G4 0SF, Lanark, Scotland Glasgow Royal Infirm Glasgow Lanark Scotland G4 0SF 0SF, Lanark, Scotland
Titolo Testata:
DIABETES RESEARCH AND CLINICAL PRACTICE
fascicolo: 2, volume: 51, anno: 2001,
pagine: 107 - 114
SICI:
0168-8227(200102)51:2<107:CRFALS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-HEART-DISEASE; LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE SYNDROME; PLASMA; OBESITY; WOMEN; MEN; HYPERINSULINEMIA; ATHEROSCLEROSIS; APOLIPOPROTEINS;
Keywords:
glycaemic control; LDL subfraction; cardiovascular risk; diabetic dyslipidaemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tan, CE Singapore Gen Hosp, Dept Endocrinol, Outram Rd, Singapore 169608, Singapore Singapore Gen Hosp Outram Rd Singapore Singapore 169608 Singapore
Citazione:
C.E. Tan et al., "Cardiovascular risk factors and LDL subfraction profile in Type 2 diabetesmellitus subjects with good glycaemic control", DIABET RE C, 51(2), 2001, pp. 107-114

Abstract

Objectives: To compare cardiovascular risk factors and LDL particle size in well-controlled Type 2 diabetes mellitus and normal subjects. Methods: Ninety-three Type 2 diabetic males and 186 age-matched, male controls were studied. Glycaemic control was stable for at least 3 months prior to recruitment. None were on insulin or lipid lowering therapy. Anthropometric indices, blood pressure, lipids, glucose, insulin, apolipoprotein Al and B, LDL subfraction by density ultracentrifugation were obtained after an overnight fast of 10 h. Results: Diabetic subjects (mean HbA(1c) 6.6% +/- 0.10) did not differ from controls in total cholesterol levels (5.04 +/- 0.08 vs. 5.16 /- 0.05 mmol/l, respectively) but had lower serum HDL cholesterol (0.98 +/- 0.03 vs. 1.12 +/- 0.02 mmol/l, P < 0.001), higher serum triglyceride (2.38 +/- 0.16 vs. 1.80 +/- 0.08 mmol/l, P < 0.001), lower LDL, and LDL, and higher LDL, concentration. An LDL, concentration exceeding 100 mg/dl was found in 59.1% of diabetics and 39.1% of non-diabetics (P < 0.001). Diabetic subjects also had higher body mass index, waist to hip ratio and insulin resistance (HOMA). Difference in LDL subfraction between groups disappeared after adjustments were made for either triglyceride or HDL cholesterol. Conclusion: Well controlled Type 2 diabetes mellitus subjects exhibit an increased cardiovascular burden through low HDL cholesterol and predominance of small, dense LDL particles. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:23:30