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Titolo:
Differential influence of LDL cholesterol and triglycerides on lipoprotein(a) concentrations in diabetic patients
Autore:
Hernandez, C; Chacon, P; Garcia-Pascual, L; Simo, R;
Indirizzi:
Hosp Gen Valle Hebron, Diabet Unit, Barcelona, Spain Hosp Gen Valle Hebron Barcelona Spain on, Diabet Unit, Barcelona, Spain Hosp Gen Valle Hebron, Dept Biochem, Barcelona, Spain Hosp Gen Valle Hebron Barcelona Spain n, Dept Biochem, Barcelona, Spain Hosp Mutua de Terrassa, Dept Endocrinol, Barcelona, Spain Hosp Mutua de Terrassa Barcelona Spain ept Endocrinol, Barcelona, Spain
Titolo Testata:
DIABETES CARE
fascicolo: 2, volume: 24, anno: 2001,
pagine: 350 - 355
SICI:
0149-5992(200102)24:2<350:DIOLCA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPROVED GLYCEMIC CONTROL; CORONARY HEART-DISEASE; SERUM LIPOPROTEIN(A); MYOCARDIAL-INFARCTION; PLASMA; LP(A); APOLIPOPROTEIN(A); PHENOTYPES; HYPERTRIGLYCERIDEMIA; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Simo, R Hosp Gen Univ Vall Hebron, Diabet Unit, Pg Vall Hebron 119-129, Barcelona 08035, Spain Hosp Gen Univ Vall Hebron Pg Vall Hebron 119-129 Barcelona Spain 08035
Citazione:
C. Hernandez et al., "Differential influence of LDL cholesterol and triglycerides on lipoprotein(a) concentrations in diabetic patients", DIABET CARE, 24(2), 2001, pp. 350-355

Abstract

OBJECTIVE- In evaluate the relationship between plasma lipid profiles and lipoprotein(a) [Lp(a)] concentrations in diabetic patients, taking into account the Lp(a) phenotype. RESEARCH DESIGN AND METHODS- We included 191 consecutive diabetic outpatients (69 type 1 and 122 type 2 diabetic patients) in a cross-sectional study. Serum Lp(a) was determined by enzyme-linked immunosorbent assay, and Lp(a) phenotypes were assessed by SDS-PAGE followed by immunoblotting. The statistical methods included a stepwise multiple regression analysis using the Lp(a) serum concentration as the dependent variable. The lipid profile consisted of total cholesterol, HDL cholesterol, LDL cholesterol, corrected LDLcholesterol, triglycerides, and apolipoproteins A1 and B. RESULTS- In the multiple regression analysis, LDL cholesterol (positively)and triglycerides (negatively) were independently related to the Lp(a) concentration, and they explained the 6.6 and 7.8% of the Lp(a) variation, repectively. After correcting LDL cholesterol, the two variables explained 3.8and 6.4% of the Lp(a) variation, respectively. In addition, we observed that serum Lp(a) concentrations were significantly lower in patients with type IV hyperlipidemia (mean 1.0 mg/dl [range 0.5-17], n = 16) than in normolipidemic patients (6.5 mg/dl [0.5-33.5]. n = 117) and in type II hyperlipidemic patients (IIa 15.5 mg/dl [3.5-75], n = 13; IIb 9 mg/dl [1-80], n = 45);P < 0.001 by analysis of variance. CONCLUSIONS- Lp(a) concentrations were directly correlated with LDL cholesterol and negatively correlated with triglyceride levels in diabetic patients. Therefore, our results suggest that the treatment of diabetic dyslipemia may indirectly affect Lp(a) concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:42:10