Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The long-term effect of low-carbohydrate/high-fat diet on the development of diabetes mellitus in spontaneously diabetic rats
Autore:
Kaneko, T; Wang, PY; Wang, Y; Sato, S;
Indirizzi:
Med Univ Yamanashi, Dept Environm Hlth, Tamaho, Yamanashi 4093898, Japan Med Univ Yamanashi Tamaho Yamanashi Japan 4093898 amanashi 4093898, Japan
Titolo Testata:
DIABETES & METABOLISM
fascicolo: 6, volume: 26, anno: 2000,
pagine: 459 - 464
SICI:
1262-3636(200012)26:6<459:TLEOLD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; MIXED MEALS; OBESITY; NIDDM; PATHOGENESIS; ACIDS;
Keywords:
low-carbohydrate/high-fat diet; type 2 diabetes mellitus; OLETF rats; glucose-fatty acid cycle; oral glucose tolerance test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kaneko, T Med Univ Yamanashi, Dept Environm Hlth, Shimokato 1110, Tamaho, Yamanashi 4093898, Japan Med Univ Yamanashi Shimokato 1110 Tamaho YamanashiJapan 4093898
Citazione:
T. Kaneko et al., "The long-term effect of low-carbohydrate/high-fat diet on the development of diabetes mellitus in spontaneously diabetic rats", DIABETE MET, 26(6), 2000, pp. 459-464

Abstract

The long-term effect of low-carbohydrate/high-fat diets on the developmentof diabetes mellitus was studied in Otsuka Long-Evans Tokushima Fatty strain (OLETF) rats. Four groups of spontaneously diabetic (type 2) male rats at 10 weeks of age were pair-fed semi-purified powder diets containing different amounts of carbohydrate (80%, 60%, 40%, 20% of total calories) for 30 weeks. The carbohydrate content was isocalorically substituted for the fat content in the diet. At the onset of experimental feeding (10 weeks of age), an oral glucose tolerance test (OGTT) was normal in each group. After 15 weeks of the test diet feeding there was no significant difference in the glucose tolerance among the 4 groups, although most of the rats were diabetic. The body weight increased with the decrease of the carbohydrate intake and increase of the fat intake (p < 0.05), and the difference increased in proportion to age (p < 0.05). The severity of diabetes mellitus was also increased along with the lower carbohydrate intake and higher fat intake, whenthe carbohydrate intake was less than 60% (in energy). On the other hand, there was a significant increase in the 20% group in the postload plasma insulin levels as compared with the other 3 groups at 40 weeks of age. Fasting plasma free fatty acid levels were increased in the lower carbohydrate content groups (20% and 40%) as compared with the higher carbohydrate contentgroups (60% and 80%) at the end of the experiment. Impairment of insulin secretion may be the cause of glucose intolerance induced by low carbohydrate intake rather than insulin resistance. These findings suggest that low-carbohydrate/high-fat diet aggravates diabetes mellitus in genetically diabetic rats, and that the development of diabetes mellitus is associated with the activation of the glucose-fatty acid cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 01:30:35