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Titolo:
Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo: Signaling by BMPs and TGF-beta s
Autore:
Flanders, KC; Kim, ES; Roberts, AB;
Indirizzi:
NCI, LCRC, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, LCRC, NIH, Bethesda, MD 20892 USA
Titolo Testata:
DEVELOPMENTAL DYNAMICS
fascicolo: 2, volume: 220, anno: 2001,
pagine: 141 - 154
SICI:
1058-8388(200102)220:2<141:IEOS1I>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; BONE MORPHOGENETIC PROTEIN-2; LUNG BRANCHING MORPHOGENESIS; TUMOR-SUPPRESSOR; MESODERM INDUCTION; TRANSFORMING GROWTH-FACTOR-BETA-1; TARGETED DISRUPTION; EPITHELIAL-CELLS; NERVOUS-SYSTEM; XENOPUS-LAEVIS;
Keywords:
Smad proteins; immunohistochemistry; mouse embryo; transforming growth factor-beta; bone morphogenetic proteins; activin; organogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Flanders, KC NCI, LCRC, NIH, Bldg 41,Rm C-629,41 Lib Dr MSC 5055, Bethesda, MD 20892 USA NCI Bldg 41,Rm C-629,41 Lib Dr MSC 5055 Bethesda MD USA 20892
Citazione:
K.C. Flanders et al., "Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo: Signaling by BMPs and TGF-beta s", DEV DYNAM, 220(2), 2001, pp. 141-154

Abstract

The eight mammalian Smad proteins mediate cellular signaling from members of the transforming growth factor-beta (TGF-beta), bone morphogenetic protein (BMP), and activin families. Smads 1, 5, and 8 transmit signals from BMPs, while Smads 2 and 3 transmit signals from TGF-betas and activin, Smad 4 is a common mediator of both pathways, while Smads 6 and 7 inhibit signaling. Signal transduction involves translocation of Smad complexes to the nucleus and subsequent gene activation. Little is known about the expression ofendogenous Smad proteins during development. We identified commercially available Smad antibodies that specifically recognize a unique Smad protein and are suitable for immunohistochemistry. Here we compare the localization of Smads 1, 2, 3, 4, 5, and 6 in tissues of the 15-day gestation mouse embryo. Immunoreactive Smad proteins are seen in many tissues with differences in the localization being dependent upon the cell type. All tissues expressSmad 4 and at least one each of the BMP-specific and TGF-beta -specific Smads, while expression of Smad 6 is more restricted. Differences are observed in the nuclear versus cytoplasmic localization among the Smads in different cell types or tissues, suggesting selective activation of Smads during this stage of development. Published 2001 Wiley-Liss, Inc.(dagger).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:31:47