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Titolo:
Bullous pemphigoid: Interaction of interleukin 5, anti-basement membrane zone antibodies and eosinophils. A preliminary observation
Autore:
Engineer, L; Bhol, K; Kumari, S; Ahmed, AR;
Indirizzi:
Harvard Univ, Sch Dent Med, Dept Oral Med & Diagnost Sci, Boston, MA 02115USA Harvard Univ Boston MA USA 02115 Med & Diagnost Sci, Boston, MA 02115USA
Titolo Testata:
CYTOKINE
fascicolo: 1, volume: 13, anno: 2001,
pagine: 32 - 38
SICI:
1043-4666(20010107)13:1<32:BPIOI5>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLISTER FLUID; MAST-CELL; INFLAMMATORY RESPONSE; PROTECTIVE IMMUNITY; BASIC-PROTEIN; T-CELLS; IGE; SERUM; RECEPTOR; DISEASE;
Keywords:
interleukin 5 (IL-5); bullous pemphigoid (BP); immunoglobulin E (IgE); eosinophils; intravenous immunoglobulin (IVIg);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Ahmed, AR Harvard Univ, Sch Dent Med, Dept Oral Med & Diagnost Sci, 188 Longwood Ave, Boston, MA 02115 USA Harvard Univ 188 Longwood Ave Boston MA USA 02115 , MA 02115 USA
Citazione:
L. Engineer et al., "Bullous pemphigoid: Interaction of interleukin 5, anti-basement membrane zone antibodies and eosinophils. A preliminary observation", CYTOKINE, 13(1), 2001, pp. 32-38

Abstract

Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the presence of autoantibodies to normal components of the hemidesmosome (BPAg1 and BPAg2), Histology of skin lesions demonstrate a subepidermal vesicle and a predominantly eosinophilic dermal cellular infiltrate, Interleukin 5 (IL-5) plays a major role in eosinophil recruitment and function. Using an ELISA, we investigated the levels of IL-5 in the sera and blister fluid of BP patients with active disease and those in prolonged clinical remission treated with intravenous immunoglobulin, and compared it to that in normal controls. Significantly increased levels of IL-5 were detected inthe serum and particularly the blister fluid of patients with active disease (P=0.0043) when compared to levels in normal controls. There was no significant difference in IL-5 levels in patients in prolonged clinical remission compared to normal control serum. Tn an immunoblot assay, using bovine gingival lysate as substrate, we determined the presence of Ige and IgE autoantibodies specific to basement membrane zone proteins in blister fluid andserum of BP patients. IgG autoantibodies to BPAg1 and BPAg2 were detected in both blister fluid and serum of patients, whereas IgE autoantibodies, inmuch lower titers, were detected to only BPAg1, Elevated levels of blood and tissue eosinophilia were observed in these patients. Based on these data, we present a preliminary hypothesis for the initiation, progression and localization of blister formation in BP. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:11:56