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Titolo:
Localization of human interleukin 13 receptor in non-haematopoietic cells
Autore:
Akaiwa, M; Yu, B; Umeshita-Suyama, R; Terada, N; Suto, H; Koga, T; Arima, K; Matsushita, S; Saito, H; Ogawa, H; Furue, M; Hamasaki, N; Ohshima, K; Izuhara, K;
Indirizzi:
Saga Med Sch, Dept Biochem, Saga 8498501, Japan Saga Med Sch Saga Japan 8498501 d Sch, Dept Biochem, Saga 8498501, Japan Kyushu Univ, Grad Sch Med Sci, Dept Clin Chem & Lab Med, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 pt Clin Chem & Lab Med, Fukuoka 812, Japan Kyushu Univ, Grad Sch Med Sci, Dept Dermatol, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 Med Sci, Dept Dermatol, Fukuoka 812, Japan UNITIKA Ltd, Inst Res & Dev, Uji, Kyoto, Japan UNITIKA Ltd Uji Kyoto Japan ITIKA Ltd, Inst Res & Dev, Uji, Kyoto, Japan Chiba Univ, Sch Med, Dept Otorhinolaryngol, Chiba 280, Japan Chiba Univ Chiba Japan 280 Med, Dept Otorhinolaryngol, Chiba 280, Japan Juntendo Univ, Dept Dermatol, Tokyo, Japan Juntendo Univ Tokyo JapanJuntendo Univ, Dept Dermatol, Tokyo, Japan Kumamoto Univ, Grad Sch Med Sci, Dept Neurosci & Immunol, Div Immunogenet,Kumamoto, Japan Kumamoto Univ Kumamoto Japan & Immunol, Div Immunogenet,Kumamoto, Japan Natl Childrens Med Res Ctr, Dept Allergy, Tokyo 154, Japan Natl Childrens Med Res Ctr Tokyo Japan 154 ept Allergy, Tokyo 154, Japan Fukuoka Univ, Sch Med, Dept Pathol, Fukuoka 81401, Japan Fukuoka Univ Fukuoka Japan 81401 Med, Dept Pathol, Fukuoka 81401, Japan
Titolo Testata:
CYTOKINE
fascicolo: 2, volume: 13, anno: 2001,
pagine: 75 - 84
SICI:
1043-4666(20010121)13:2<75:LOHI1R>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
IL-13 MESSENGER-RNA; PERENNIAL ALLERGIC RHINITICS; HUMAN B-CELLS; T-CELLS; ADHESION MOLECULE-1; ATOPIC-DERMATITIS; ENDOTHELIAL-CELLS; NASAL-MUCOSA; ALPHA CHAIN; TH2 CELLS;
Keywords:
interleukin 13; receptor; keratinocyte; epithelial cell; smooth muscle cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Izuhara, K Saga Med Sch, Dept Biochem, 5-1-1 Nabeshima, Saga 8498501, Japan Saga Med Sch 5-1-1 Nabeshima Saga Japan 8498501 8498501, Japan
Citazione:
M. Akaiwa et al., "Localization of human interleukin 13 receptor in non-haematopoietic cells", CYTOKINE, 13(2), 2001, pp. 75-84

Abstract

Although the functional roles of interleukin (IL-)13 in haematopoietic cells are well investigated, those in non-haematopoietic cells remain to be addressed. IL-13 exerts its actions by binding to the IL-13 receptor (IL-13R)on target cells, which is composed of IL-13R alpha1 and the IL-4 receptor alpha chain (IL-4R alpha), However, there has been no study of localizationof IL-13R in each tissue. To address this question, we generated monoclonal anti-IL-13R alpha1 antibody, and performed immunohistochemistry using this antibody and anti-IL-4R alpha antibody. Distribution of these two components was the same in all examined tissues. Staining was positive in keratinocytes, hair follicles, and sebaceous and sweat glands in skin; in ciliated respiratory epithelial cells in nasal tissue; in heart muscle cells; in foveola cells, gastric glands, and the smooth muscle layer in stomach; and in hepatocytes in liver. However, staining was undetectable in brain and bone marrow. Fibroblasts and endothelial cells were stained in some tissues. These results provide clues to elucidate the known pathological roles of IL-13in atopic dermatitis and allergic rhinitis, as well as its unknown physiological roles. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 18:45:08