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Titolo:
The von Hippel-Lindau tumor suppressor protein
Autore:
Ivan, M; Kaelin, WG;
Indirizzi:
Dana Farber Canc Inst, Howard Hughes Med Inst, Boston, MA 02115 USA Dana Farber Canc Inst Boston MA USA 02115 Med Inst, Boston, MA 02115 USA Brigham & Womens Hosp, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 mens Hosp, Boston, MA 02115 USA
Titolo Testata:
CURRENT OPINION IN GENETICS & DEVELOPMENT
fascicolo: 1, volume: 11, anno: 2001,
pagine: 27 - 34
SICI:
0959-437X(200102)11:1<27:TVHTSP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; BIOLOGICALLY-ACTIVE PRODUCT; POLYCYSTIC KIDNEY-DISEASE; UBIQUITIN LIGASE COMPLEX; RENAL-CARCINOMA CELLS; SOCS-BOX MOTIF; GENE-PRODUCT; ELONGIN-C; TYROSINE-HYDROXYLASE; NERVOUS-SYSTEM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Ivan, M Dana Farber Canc Inst, Howard Hughes Med Inst, 44 Binney St, Boston, MA 02115 USA Dana Farber Canc Inst 44 Binney St Boston MA USA 02115 A 02115 USA
Citazione:
M. Ivan e W.G. Kaelin, "The von Hippel-Lindau tumor suppressor protein", CUR OP GEN, 11(1), 2001, pp. 27-34

Abstract

The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric transcription factorHIF (hypoxia inducible factor). pVHL directs the polyubiquitination and, hence, destruction of HIF in the presence of oxygen. Loss of pVHL function leads to deregulation of HIF target genes, which play critical roles in angiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 10:00:16