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Titolo:
Deficits in sensorimotor control during precise hand movements in Huntington's disease
Autore:
Schwarz, M; Fellows, SJ; Schaffrath, C; Noth, J;
Indirizzi:
Rhein Westfal TH Aachen, Univ Klinikum, Neurol Klin, D-52057 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-52057 , D-52057 Aachen, Germany Stadt Klinikun Dortmund, Neurol Klin, D-44137 Dortmund, Germany Stadt Klinikun Dortmund Dortmund Germany D-44137 44137 Dortmund, Germany
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 1, volume: 112, anno: 2001,
pagine: 95 - 106
SICI:
1388-2457(200101)112:1<95:DISCDP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOSENSORY-EVOKED-POTENTIALS; UNPREDICTABLE PULLING LOADS; INDUCED TRANSIENT POTENTIATION; PARKINSONS-DISEASE; BASAL GANGLIA; MANIPULATIVE FORCES; FRONTAL COMPONENTS; BRAIN-STIMULATION; MOTOR-RESPONSES; GRIP;
Keywords:
Huntington's disease; sensorimotor; precision grip; basal ganglia; cerebellum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Fellows, SJ Rhein Westfal TH Aachen, Univ Klinikum, Neurol Klin, Pauwelsstr 30, D-52057 Aachen, Germany Rhein Westfal TH Aachen Pauwelsstr 30 AachenGermany D-52057
Citazione:
M. Schwarz et al., "Deficits in sensorimotor control during precise hand movements in Huntington's disease", CLIN NEU, 112(1), 2001, pp. 95-106

Abstract

Objectives: To investigate the performance of patients with Huntington's disease (HD) while manipulating objects using a precision grip. Methods: The grip forces developed by the fingers were studied while subjects lifted an object of unpredictable weight in the hand. The ability to stabilize grip force after externally imposed weight change was also studied. Results: patients used higher grip forces than the normal subjects in boththe lifting and holding phases, particularly with a lighter weight. Lift timing was slowed in the patients, most markedly with a lighter weight. Increased levels of inter-trial variation were observed only with a light weight. This indicates that the slowing in HD differs from that in Parkinson's disease, which remains constant regardless of object load, and that the slowing in HD is not due to involuntary antagonist muscle activity resulting from an underlying chorea. The grip force response to sudden weight change was normal, but appeared after a delay which increased at lower rates of weight change. Conclusions: Disturbances in precision grip timing and magnitude in HD mayresult from a reduced ability to process relevant tactile afferent input. The delay in the adaptive response suggests an increased threshold for detection of weight change in HD. Alternatively, this delay may arise from mediation of the response over an additional cerebellar pathway to compensate for damage to the basal ganglia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 11/07/20 alle ore 04:38:16