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Titolo:
Investigation of non-linear properties of multichannel EEG in the early stages of Parkinson's disease
Autore:
Pezard, L; Jech, R; Ruzicka, E;
Indirizzi:
Charles Univ, Neurol Clin, CZ-12000 Prague 2, Czech Republic Charles UnivPrague Czech Republic 2 , CZ-12000 Prague 2, Czech Republic Univ Paris 05, Lab Neurosci Comportementales, F-75270 Paris, France Univ Paris 05 Paris France F-75270 mportementales, F-75270 Paris, France
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 1, volume: 112, anno: 2001,
pagine: 38 - 45
SICI:
1388-2457(200101)112:1<38:IONPOM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-SERIES; NONLINEAR STRUCTURE; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; BRAIN ACTIVITY; DYNAMICS; CHAOS; COMPLEXITY; DEPRESSION; DECREASE;
Keywords:
Parkinson's disease; EEG; spectral analysis; non-linear dynamics; entropy; surrogate data;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Ruzicka, E Charles Univ, Neurol Clin, Katerinska 30, CZ-12000 Prague 2, Czech Republic Charles Univ Katerinska 30 Prague Czech Republic 2 ch Republic
Citazione:
L. Pezard et al., "Investigation of non-linear properties of multichannel EEG in the early stages of Parkinson's disease", CLIN NEU, 112(1), 2001, pp. 38-45

Abstract

Objectives: Modifications of brain activity in the early stages of Parkinson's disease (PD) are difficult to detect using electroencephalography (EEG) signals and are often biased by L-DOPA treatment. We compare here the performances of both linear and non-linear methods in differentiating EEG of L-DOPA naive PD patients from that of control subjects. Methods: Resting multichannel EEG (20 electrodes, 30 s epochs) of 9 patients with PD in Hoehn and Yahr stages 1-2 (4 women, 5 men, mean age 54.3 years, range 48-63 years) were compared with those of 9 control subjects (7 women, two men, mean age 51.3 years, range 43-61 years). The following measurements were computed: theta-, alpha- and beta -band relative powers constituted the linear indices: localized entropy, slope asymmetry and number of non-linear EEG segments constituted the non-linear indices. Results: In the case of linear quantification, only a decrease in the beta-band was observed for patients. Significant non-linear structures were observed in our EEG data. Non-linear quantifiers demonstrate an increase in entropy and in the number of non-linear EEG segments for the patients. Conclusions: Changes in EEG dynamics observed hen in L-DOPA naive PD patients may represent early signs of cortical dysfunction produced by subcortical dopamine depletion. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 27/01/20 alle ore 17:58:15