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Titolo:
Candida lusitaniae: A cause of breakthrough fungemia in cancer patients
Autore:
Minari, A; Hachem, R; Raad, I;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Internal Med Specialties, Sect Infect Control, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 ect Infect Control, Houston, TX 77030 USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 2, volume: 32, anno: 2001,
pagine: 186 - 190
SICI:
1058-4838(20010115)32:2<186:CLACOB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHOTERICIN-B; OPPORTUNISTIC PATHOGEN; FLUCONAZOLE; RESISTANCE; THERAPY; INFECTION; FREQUENCY; EMERGENCE; ALBICANS; SEPSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Raad, I Univ Texas, MD Anderson Canc Ctr, Dept Internal Med Specialties, Sect Infect Control, Box 47,1515 Holcombe Blvd, Houston, TX 77030 USA Univ Texas Box 47,1515 Holcombe Blvd Houston TX USA 77030 7030 USA
Citazione:
A. Minari et al., "Candida lusitaniae: A cause of breakthrough fungemia in cancer patients", CLIN INF D, 32(2), 2001, pp. 186-190

Abstract

Candida lusitaniae is an infrequent cause of fungemia. We identified 12 cases of C. lusitaniae fungemia that occurred at the University of Texas M. D. Anderson Cancer Center from 1988 to 1999. The mean age of patients was 48years (range 20-70 years). Eight patients had hematologic malignancy or had received a bone marrow transplant, and 4 had a solid tumor. Most patients(75%) were neutropenic (<10(3)/mm(3)). Treatment with amphotericin B alonefailed for 3 of 6 patients, irrespective of neutropenic status. Fluconazole was effective as a single agent in 3 patients with solid tumors. The combination of amphotericin B plus fluconazole was effective treatment for two-thirds of patients with hematologic malignancy, despite persistence of neutropenia. The mortality rate associated with C. lusitaniae infection was 25%. C. lusitaniae presents as breakthrough fungemia in immunocompromised patients and is associated with failure of amphotericin B therapy. Fluconazole may be a useful agent in the treatment of this infection.

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Documento generato il 04/07/20 alle ore 11:50:12