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Titolo:
Sleep-disordered breathing in patients referred for angina evaluation - Association with left ventricular dysfunction
Autore:
Sanner, BM; Konermann, M; Doberauer, C; Weiss, T; Zidek, W;
Indirizzi:
Ruhr Univ Bochum, Marien Hosp, Dept Med 1, D-44625 Herne, Germany Ruhr Univ Bochum Herne Germany D-44625 ept Med 1, D-44625 Herne, Germany
Titolo Testata:
CLINICAL CARDIOLOGY
fascicolo: 2, volume: 24, anno: 2001,
pagine: 146 - 150
SICI:
0160-9289(200102)24:2<146:SBIPRF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; CHEYNE-STOKES RESPIRATION; CONGESTIVE-HEART-FAILURE; POSITIVE AIRWAY PRESSURE; APNEA SYNDROME; PULMONARY-HYPERTENSION; PREVALENCE; MORTALITY; MEN;
Keywords:
obstructive sleep apnea; coronary artery disease; cardiovascular morbidity; coronary angiography; left ventricular dysfunction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sanner, BM Ruhr Univ Bochum, Marien Hosp, Dept Med 1, Hoelkeskampring 40, D-44625 Herne, Germany Ruhr Univ Bochum Hoelkeskampring 40 Herne Germany D-44625 many
Citazione:
B.M. Sanner et al., "Sleep-disordered breathing in patients referred for angina evaluation - Association with left ventricular dysfunction", CLIN CARD, 24(2), 2001, pp. 146-150

Abstract

Background: Clinical observations have linked sleep-disordered breathing to cardiovascular morbidity and mortality, and especially to coronary arterydisease. Hypothesis: The study was undertaken to determine the prevalence of sleep-disordered breathing in consecutive patients referred for angina evaluation, and analyzed the parameters influencing the severity of sleep-disordered breathing. Methods: In all, 68 consecutive patients (53 men, 15 women, aged 63.4 +/- 10.0 years) referred for angina evaluation were studied. Coronary angiography, selective left ventriculography. and a polygraphic study with a validated six-channel monitoring device were performed. Full-night polysomnographywas used to reevaluate patients with an apnea/hypopnea index greater than or equal to 10/h. Results: Sleep-disordered breathing as defined by an apnea/hypopnea index greater than or equal to 10/h was found in 30.9% of patients; its prevalence was not increased in patients with and without coronary artery disease (26.5 vs. 42.1). Multiple stepwise Linear regression analysis revealed that the severity of sleep-disordered breathing was significantly and independently associated with left ventricular ejection fraction (r = -0.38; p = 0.002). but not with age, body mass index, gender, diabetes mellitus, hypertension, hyperuricemia, hypercholesterolemia, smoking habits, or coronary arterydisease. In this group of patients, multiple logistic regression analysis could not demonstrate sleep-disordered breathing to be an independent predictor of coronary artery disease. Conclusions: Sleep-disordered breathing is common in patients referred forangina evaluation. The degree of sleep-disordered breathing is mainly determined by the extent of left ventricular dysfunction.

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Documento generato il 31/03/20 alle ore 16:29:37