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Titolo:
The role of ion pairing in the chromatographic study of propranolol analogues
Autore:
Britto, MM; Cass, QB; Jardim, ICSF; Montanari, CA; Aboul-Enein, HY;
Indirizzi:
King Faisal Specialist Hosp & Res Ctr, Dept Biol & Med Res, Pharmaceut Anal Lab, Riyadh 11211, Saudi Arabia King Faisal Specialist Hosp & Res Ctr Riyadh Saudi Arabia 11211 i Arabia Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil Univ Fed Minas Gerais Belo Horizonte MG Brazil BR-31270901 BC, MG, Brazil Univ Fed Sao Carlos, Dept Quim, BR-13560 Sao Carlos, SP, Brazil Univ Fed Sao Carlos Sao Carlos SP Brazil BR-13560 Sao Carlos, SP, Brazil Univ Estadual Campinas, Inst Quim, Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil nst Quim, Campinas, SP, Brazil
Titolo Testata:
CHROMATOGRAPHIA
fascicolo: 1-2, volume: 53, anno: 2001,
pagine: 11 - 16
SICI:
0009-5893(200101)53:1-2<11:TROIPI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; REVERSED-PHASE CHROMATOGRAPHY; PARTITION-COEFFICIENTS; LIPOPHILICITY PROFILES; IONIZABLE DRUGS; BLOCKING-AGENTS; PH; MECHANISMS; RETENTION;
Keywords:
column liquid chromatography; structure-retention relationships; propranolol analogues;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Britto, MM King Faisal Specialist Hosp & Res Ctr, Dept Biol & Med Res, Pharmaceut Anal Lab, MBC-03,POB 3354, Riyadh 11211, Saudi Arabia King Faisal Specialist Hosp & Res Ctr MBC-03,POB 3354 Riyadh Saudi Arabia 11211
Citazione:
M.M. Britto et al., "The role of ion pairing in the chromatographic study of propranolol analogues", CHROMATOGR, 53(1-2), 2001, pp. 11-16

Abstract

The partition coefficients, log P-app(RPLC), for a series of propranolol analogues have been determined by reversed phase high performance liquid chromatography. The hydrochloride salts and free base log P-app(RPLC) show that charged and uncharged species can partition into the reversed phase. An extrathermodynamic relationship was found for log P-app(RPLC) measured in two different column stationary phases, C8 and PMOS, suggesting that the samesei of compounds experience a similar trend in these elution systems. The importance of using phosphate and/or MOPS buffer is due to the fact that the latter can avoid ion-pairing partitioning, but the former does play the same role for PMOS column when the free base is considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:35:15