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Titolo:
The role of Ras and other low molecular weight guanine nucleotide (GTP)-binding proteins during hematopoietic cell differentiation
Autore:
Scheele, JS; Rapple, D; Lubbert, M;
Indirizzi:
Univ Freiburg, Dept Med, Div Hematol & Oncol, Med Ctr, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 ed Ctr, D-79106 Freiburg, Germany
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 13-14, volume: 57, anno: 2000,
pagine: 1950 - 1963
SICI:
1420-682X(200012)57:13-14<1950:TRORAO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; GTP-BINDING PROTEINS; CHRONIC MYELOMONOCYTIC LEUKEMIA; NEUROFIBROMATOSIS TYPE-1 GENE; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; GDP/GTP EXCHANGE PROTEINS; POLYMERASE CHAIN-REACTION; BOVINE BRAIN CYTOSOL; VARIANT HL-60 CELLS;
Keywords:
cell differentiation; gene expression; Ras; Rap; Rho; Rab; ARF; Ran; Rad;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
154
Recensione:
Indirizzi per estratti:
Indirizzo: Scheele, JS Univ Freiburg, Dept Med, Div Hematol & Oncol, Med Ctr, Hugstetter Str 55, D-79106 Freiburg, Germany Univ Freiburg Hugstetter Str 55 Freiburg Germany D-79106 many
Citazione:
J.S. Scheele et al., "The role of Ras and other low molecular weight guanine nucleotide (GTP)-binding proteins during hematopoietic cell differentiation", CELL MOL L, 57(13-14), 2000, pp. 1950-1963

Abstract

Recent progress in the understanding of signal transduction and gene regulation in hematopoietic cells has shown that many intracellular signalling pathways are modulated by low molecular weight guanine nucleotide (GTP)-binding proteins (LMWGs). LMWGs act as molecular switches for regulating a widerange of signal-transduction pathways in virtually all cells. In hematopoietic cells, LMWGs have been shown to participate in essential functions such as growth control, differentiation, cytoskeletal organization, cytokine and chemoattractant-induced signalling events, reduced nicotinamide adenine dinucleotide phosphate oxidase activity, intracellular vesicle transport and secretion. In human leukemias, myelodysplastic syndromes and myeloproliferative disorders, Ras activation occurs by point mutations, overexpression or by alteration of NF-1 Ras-GTPase activating protein (GAP). These are postinitiation events in leukemia but may modulate growth-factor-dependent andindependent leukemic growth. Two animal models of mutated N-ras expressionresulting in myelodysplastic and myeloproliferative features are discussed. The role of Ras in organ development is discussed in the context of transgenic knockout mice. More LMWG functions will certainly be identified as wegain a better understanding of regulatory pathways modulating myeloid signal transduction. This review will summarize our current understanding of this rapidly advancing area of research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:45:07