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Titolo:
Loss of heterozygosity at 3p24-p25 as a prognostic factor in breast cancer
Autore:
Matsumoto, S; Minobe, K; Utada, Y; Furukawa, K; Onda, M; Sakamoto, G; Kasumi, F; Nakamura, Y; Emi, M;
Indirizzi:
Nippon Med Sch, Inst Gerontol, Dept Mol Biol, Nakahara Ku, Kawasaki, Kanagawa 2118533, Japan Nippon Med Sch Kawasaki Kanagawa Japan 2118533 i, Kanagawa 2118533, Japan Nippon Med Sch, Dept Surg 1, Bunkyo Ku, Tokyo 1138602, Japan Nippon Med Sch Tokyo Japan 1138602 rg 1, Bunkyo Ku, Tokyo 1138602, Japan Inst Canc, Dept Surg & Pathol, Toshima Ku, Tokyo 1708455, Japan Inst CancTokyo Japan 1708455 & Pathol, Toshima Ku, Tokyo 1708455, Japan Univ Tokyo, Inst Med Sci, Mol Med Lab, Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 Med Lab, Minato Ku, Tokyo 1088639, Japan
Titolo Testata:
CANCER LETTERS
fascicolo: 1, volume: 152, anno: 2000,
pagine: 63 - 69
SICI:
0304-3835(20000428)152:1<63:LOHA3A>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FHIT GENE; T(3-8) BREAKPOINT; CELL CARCINOMA; CHROMOSOME 3P; LUNG-CANCER; SHORT ARM; DELETION; REGION; AMPLIFICATION; SURVIVAL;
Keywords:
breast cancer; chromosome 3p; loss of heterozygosity; tumor suppressor gene; postoperative mortality;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Emi, M Nippon Med Sch, Inst Gerontol, Dept Mol Biol, Nakahara Ku, 1-396 Kusugi Cho, Kawasaki, Kanagawa 2118533, Japan Nippon Med Sch 1-396 Kusugi ChoKawasaki Kanagawa Japan 2118533 pan
Citazione:
S. Matsumoto et al., "Loss of heterozygosity at 3p24-p25 as a prognostic factor in breast cancer", CANCER LETT, 152(1), 2000, pp. 63-69

Abstract

Differences in clinical course and biological characteristics among breastcancers will probably be explained ultimately by variations in the patternof genetic alterations among the many genes that can play roles in carcinogenesis. Loss of heterozygosity (LOH) of a particular chromosomal region ina tumor, which presumably indicates loss of a growth-regulating 'tumor-suppressor' gene in that region, may represent a useful marker for postoperative prognosis. In earlier work we observed LOH at chromosomal regions 3p14-p21 and/or 3p24-p25 in a large proportion of breast cancers. To examine whether allelic losses in either of those regions might correlate with postoperative survival, we tested tumors from a cohort of 504 breast cancer patients for allelic losses of microsatellite markers in the relevant portions of chromosome 3p. Five years postoperatively, patients whose tumors had undergone LOH at 3p24-p5 were found to have borne significantly higher risks of mortality than women whose tumors retained both alleles at that locus; i.e. the 5-year mortality rate was 22% among patients with losses at 3p24-p25 vs. 9% with retentions of heterozygosity at that locus (P = 0.0014). These data indicate that LOH at 3p2d-p25 is a significant predictive factor for postoperative survival of patients who have undergone surgery for breast cancer. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:24:34