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Titolo:
Altered p21(WAF1/CIP1) expression is associated with poor prognosis in extrahepatic bile duct carcinoma
Autore:
Li, X; Hui, AM; Takayama, T; Cui, X; Shi, Y; Makuuchi, M;
Indirizzi:
Univ Tokyo, Grad Sch Med, Dept Surg, Hepatobiliary Pancreat Surg Div,Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 Surg Div,Bunkyo Ku, Tokyo 1138655, Japan
Titolo Testata:
CANCER LETTERS
fascicolo: 1, volume: 154, anno: 2000,
pagine: 85 - 91
SICI:
0304-3835(20000601)154:1<85:APEIAW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR SUPPRESSION; DNA-REPLICATION; P53 PROTEIN; CELL-CYCLE; P21; SURVIVAL; CANCER; INHIBITOR; MUTATIONS; KINASES;
Keywords:
p21(WAFI/CIP1); p53; extrahepatic bile duct carcinoma; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Makuuchi, M Univ Tokyo, Grad Sch Med, Dept Surg, Hepatobiliary Pancreat Surg Div,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138655 kyo 1138655, Japan
Citazione:
X. Li et al., "Altered p21(WAF1/CIP1) expression is associated with poor prognosis in extrahepatic bile duct carcinoma", CANCER LETT, 154(1), 2000, pp. 85-91

Abstract

This study was designed to determine the clinical implications of p21(WAF1/CIP1) expression and the relationship between p21(WAF1/CIP1) expression and p53 status in extrahepatic bile duct carcinoma (EBDC). Low p21(WAF1/CIP1)expression was immunohistochemically detected in 23 (67.6%) of 34 EBDCs, moderate in six (17.7%), and high in five (14.7%). Kaplan-Meier curves showed that low and high p21(WAF1/CIP1) expressions were significantly associated with shortened disease-free survival (low vs. moderate, P = 0.02; high vs. moderate, P = 0.01). There was no correlation between p21(WAF1/CIP1) and p53 expression. These findings suggest that altered p21(WAF1/CIP1) expression exerts an adverse influence on the prognosis of EBDC. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:36:33